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Overview

  • Product nameAnti-Mesothelin antibodySee all Mesothelin primary antibodies ...
  • Description
    Rabbit polyclonal to Mesothelin
  • Tested applicationsWB, IHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 44 and 438 of Human Mesothelin (NP_037536).

  • Positive controlWB: 293T cell lysate IHC-P: serous OVCA

Properties

Applications

Our Abpromise guarantee covers the use of ab96869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/3000. Predicted molecular weight: 69 kDa.
IHC-P IHC-P: 1/100.

Target

  • FunctionMembrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • Tissue specificityExpressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • Involvement in diseaseNote=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • Sequence similaritiesBelongs to the mesothelin family.
  • Post-translational
    modifications    Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Cellular localizationSecreted and Cell membrane. Golgi apparatus.

    • Target information above from: UniProt accession Q13421 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CAK 1 antibodyCAK1 antibodyCAK1 antigen antibody
        cleaved form antibodyMegakaryocyte potentiating factor antibodyMesothelin antibodyMesothelin isoform 1 precursor antibodyMPF antibodyMsln antibodyMSLN_HUMAN antibodyPre pro megakaryocyte potentiating factor antibodyPre-pro-megakaryocyte-potentiating factor antibodySMR antibodySMRP antibodySoluble MPF mesothelin related protein antibody
      see all

    Anti-Mesothelin antibody images

    • Western blot - Mesothelin antibody (ab96869)
      Western blot - Mesothelin antibody (ab96869)
      Anti-Mesothelin antibody (ab96869) at 1/1000 dilution + 293T whole cell lysate at 30 µg

      Predicted band size : 69 kDa
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mesothelin antibody (ab96869)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Mesothelin antibody (ab96869)
      Immunohistochemical analysis of Mesothelin in paraffin embedded serous OVCA, using ab96869 at a 1/100 dilution.

    References for Anti-Mesothelin antibody (ab96869)

    ab96869 has not yet been referenced specifically in any publications.

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