Overview

  • Product nameAnti-Mesothelin antibody
    See all Mesothelin primary antibodies
  • Description
    Rabbit polyclonal to Mesothelin
  • Tested applicationsWB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein fragment corresponding to a region within amino acids 44 and 438 of Human Mesothelin (NP_037536).

  • Positive control
    • WB: 293T cell lysate IHC-P: serous OVCA

Properties

Applications

Our Abpromise guarantee covers the use of ab96869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 69 kDa.
IHC-P 1/100.

Target

  • FunctionMembrane-anchored forms may play a role in cellular adhesion.
    Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
  • Tissue specificityExpressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
  • Involvement in diseaseNote=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer.
  • Sequence similaritiesBelongs to the mesothelin family.
  • Post-translational
    modifications
    Both MPF and the cleaved form of mesothelin are N-glycosylated.
    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
  • Cellular localizationSecreted and Cell membrane. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CAK 1 antibody
    • CAK1 antibody
    • CAK1 antigen antibody
    • cleaved form antibody
    • Megakaryocyte potentiating factor antibody
    • Mesothelin antibody
    • Mesothelin isoform 1 precursor antibody
    • MPF antibody
    • Msln antibody
    • MSLN_HUMAN antibody
    • Pre pro megakaryocyte potentiating factor antibody
    • Pre-pro-megakaryocyte-potentiating factor antibody
    • SMR antibody
    • SMRP antibody
    • Soluble MPF mesothelin related protein antibody
    see all

Anti-Mesothelin antibody images

  • Anti-Mesothelin antibody (ab96869) at 1/1000 dilution + 293T whole cell lysate at 30 µg

    Predicted band size : 69 kDa
  • Immunohistochemical analysis of Mesothelin in paraffin embedded serous OVCA, using ab96869 at a 1/100 dilution.

References for Anti-Mesothelin antibody (ab96869)

ab96869 has not yet been referenced specifically in any publications.

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