Anti-Mesothelioma antibody [HBME-1] (ab2383)
Key features and details
- Mouse monoclonal [HBME-1] to Mesothelioma
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgM
Overview
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Product name
Anti-Mesothelioma antibody [HBME-1]
See all Mesothelioma primary antibodies -
Description
Mouse monoclonal [HBME-1] to Mesothelioma -
Host species
Mouse -
Specificity
This antibody reacts with an unknown antigen on microvilli of mesothelioma cells. It stains normal mesothelial cells as well as epithelial mesothelimias in a thick membrane pattern due to abundant lung microvilli on the surface of these cells. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Mesothelioma. Suspension of human mesothelioma cells from patients with malignant epithelial mesothelioma
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Positive control
- Mesothelioma.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.3
Preservative: 0.05% Sodium azide
Constituent: 1% BSA -
Concentration information loading...
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Purity
Purified IgM -
Clonality
Monoclonal -
Clone number
HBME-1 -
Myeloma
unknown -
Isotype
IgM -
Light chain type
unknown -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab2383 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/15 - 1/25. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Primary incubation for 30 minutes at room temperature. |
Notes |
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IHC-P
1/15 - 1/25. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Primary incubation for 30 minutes at room temperature. |
Target
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Relevance
Mesothelioma is a rare form of carcinoma of the mesothelial cells which that normally line the body cavities, including the pleura, peritoneum, pericardium, and testis. It may be localized or diffuse. Most, but not all, cases of pleural malignant mesothelioma are associated with asbestos exposure. -
Alternative names
- Malignant mesothelioma susceptibility to antibody
- MMS antibody
Images
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Formalin-fixed, paraffin-embeded human mesothelioma tissue stained for Mesothelioma using ab2383 at 1/15 dilution in immunohistochemical analysis. Antigen retrieval with citrate buffer pH 6.0
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ab2383 staining human mesothelioma by IHC-P.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human mesothelioma tissue, staining Mesothelioma with ab2383.
Datasheets and documents
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Datasheet download
References (4)
ab2383 has been referenced in 4 publications.
- Chang Z et al. PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma. Aging (Albany NY) 12:9292-9310 (2020). PubMed: 32428871
- Chernova T et al. Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). Curr Biol 27:3302-3314.e6 (2017). PubMed: 29112861
- Manzoni M et al. Solid cell nests of the thyroid gland: morphological, immunohistochemical and genetic features. Histopathology 68:866-74 (2016). PubMed: 26334919
- Pagni F et al. Proteomics in thyroid cytopathology: Relevance of MALDI-imaging in distinguishing malignant from benign lesions. Proteomics 16:1775-84 (2016). PubMed: 27029406