You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-Met (c-Met) antibody, prediluted (ab27492)

Submit an Abreview Q&A (1)

Overview

  • Product nameAnti-Met (c-Met) antibody, predilutedSee all Met (c-Met) primary antibodies ...
  • Description
    Rabbit polyclonal to Met (c-Met), prediluted
  • Specificityab27492 recognises c-Met.
  • Tested applicationsIHC-P more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: VDTRPASFWETS , corresponding to C terminal amino acids 1379-1390 of Human Met (c-Met)

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlA431 cells. Human breast carcinoma. Human ovarian carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab27492 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P IHC-P: 1/1. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • FunctionReceptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
  • Involvement in diseaseNote=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
    Note=Defects in MET may be associated with gastric cancer.
    Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550].
    Defects in MET are a cause of renal cell carcinoma papillary (RCCP) [MIM:605074]. It is a subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into common renal cell carcinoma (clear cell, non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
    Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.
    Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 3 IPT/TIG domains.
    Contains 1 protein kinase domain.
    Contains 1 Sema domain.
  • DomainThe kinase domain is involved in SPSB1 binding.
  • Post-translational
    modifications    Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P08581 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        AUTS9 antibodyc met antibodyc met antibody
        cmet antibodycmet antibodyD249 antibodyHepatocyte growth factor receptor antibodyHepatocyte growth factor receptor Precursor antibodyHepatocyte growth factor receptor Precursor antibodyHGF antibodyHGF receptor antibodyHGF receptor antibodyHGF SF receptor antibodyHGF SF receptor antibodyHGF/SF receptor antibodyHGFR antibodyHGFR antibodyMET antibodyMet proto oncogene tyrosine kinase antibodyMet proto oncogene tyrosine kinase antibodyMet proto-oncogene (hepatocyte growth factor receptor) antibodyMet proto-oncogene antibodyMet protooncogene antibodyMET_HUMAN antibodyOncogene MET antibodyOncogene MET antibodyPar4 antibodyProto-oncogene c-Met antibodyRCCP2 antibodyRCCP2 antibodyRenal cell carcinoma papillary 2 gene antibodyRenal cell carcinoma papillary 2 gene antibodyScatter factor receptor antibodySF receptor antibodyTyrosine-protein kinase Met antibody
      see all

    Anti-Met (c-Met) antibody, prediluted images

    • Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Met (c-Met) antibody, prediluted (ab27492)
      Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - Met (c-Met) antibody, prediluted (ab27492)
      Paraffin embedded formalin fixed human ovarian carcinoma tissue section stained with anti c-Met (ab27492).

    References for Anti-Met (c-Met) antibody, prediluted (ab27492)

    ab27492 has not yet been referenced specifically in any publications.

    Publishing research using ab27492 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab27492 Submit a Question for ab27492

    Displaying 1 - 1 of 1 results for Abreviews and Q&A

    10
    Votes: Highest First

    We would like to use this antibody (or any other that would recognize the C-terminal of Met) for Immunoflourescence. Is it possible for us to get/buy a small sample of the antibody? If it works, we would be happy to provide the images to you.

    Thank you for your enquiry. We do not routinely offer free or trial sized samples for testing purposes. Our policy at Abcam is that if an antibody does not work as specified on the datasheet, we will offer a replacement or reimbursement. Should you ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"