Overview

  • Product name
    Methysticin
  • Description
    CYP1A1 inducer. NaV channel inhibitor.
  • Biological description
    CYP1A1 inducer. NaV channel inhibitor. Reversibly blocks epileptiform activity (IC50 = 10-100 μM). Shows anxiolytic, anti-ischemic, anticonvulsant and neuroprotective effects in vivo. Orally active.
  • Purity
    > 98%

Properties

  • Chemical name
    (2R)-2-[(E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
  • Molecular weight
    274.27
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C15H14O5
  • CAS Number
    495-85-2
  • PubChem identifier
    5281567
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COC1=CC(=O)OC(C1)C=CC2=CC3=C(C=C2)OCO3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Magura EI  et al. Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Neuroscience 81:345-51 (1997). Read more (PubMed: 9300426) »
  • Schmitz D  et al. Effects of methysticin on three different models of seizure like events studied in rat hippocampal and entorhinal cortex slices. Naunyn Schmiedebergs Arch Pharmacol 351:348-55 (1995). Read more (PubMed: 7630425) »
  • Backhauss C & Krieglstein J Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. Eur J Pharmacol 215:265-9 (1992). Read more (PubMed: 1396990) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143519.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up