Anti-Mint3 antibody (ab3450)
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPBS, 1 mg/ml BSA and 0.05% sodium azide
- Concentration information loading...
- PurityImmunogen affinity purified
- Primary antibody notes The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to munc-18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint 3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer’s Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint 3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer’s disease.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab3450 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
By Western blot, this antibody detects an ~86 kDa protein representing Mint 3 from AtT20 cell extract.
- RelevanceMint3 is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This protein is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
- Cellular localizationCytoplasm; perinuclear region.
- Adapter protein X11gamma antibodyamyloid beta (A4) precursor protein binding, family A, member 3 antibodyAmyloid beta A4 precursor protein-binding family A member 3 antibody
- Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein antibodyAPBA3 antibodylin 10 antibodyMGC:15815 antibodyMint 3 antibodyNeuron specific X11L2 protein antibodyNeuronal Munc18 1 interacting protein 3 antibodyphosphotyrosine binding/interacting domain (PTB) bearing protein antibodyX11 like 2 protein 2 antibodyX11gamma antibodyX11L2 antibody
References for Anti-Mint3 antibody (ab3450)
ab3450 has not yet been referenced specifically in any publications.