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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid
Overview
Product name
Anti-Mint3 antibody
See all Mint3 products (2) ...
Description
Rabbit polyclonal to Mint3
Tested applications
ICC/IF, WBmore details
Cross reactivity
Reacts with
Mouse, Rat
Immunogen
Synthetic peptide: MEFLPEPQHPPGPPTMDLE, corresponding to amino acids 1-19 of Rat Mint3.
MEFLPEPQHP PGPPTMDLE
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1 mg/ml BSA and 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to munc-18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint 3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer’s Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint 3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer’s disease.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Cell Adhesion Proteins >> ECM Proteins
Neuroscience >> Neurotransmission >> Secretory Vesicles >> Other
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Amyloid
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Western blot - Mint3 antibody (ab3450)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab3450 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
Western Blot: use at a concentration of 2 µg/ml.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
By Western blot, this antibody detects an ~86 kDa protein representing Mint 3 from AtT20 cell extract.
Target
Relevance
Mint3 is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This protein is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
Alternative names
- Adapter protein X11gamma antibody
- amyloid beta (A4) precursor protein binding, family A, member 3 antibody
- Amyloid beta precursor protein binding, family A, member 3 phosphotyrosine binding/ interacting domain (PTB) bearing protein antibody
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Database links
- Entrez Gene: 57267 Mouse
- Entrez Gene: 83611 Rat
- SwissProt: O88888 Mouse
- SwissProt: O70248 Rat
Anti-Mint3 antibody images:
References for Anti-Mint3 antibody (ab3450)
ab3450 has not yet been referenced specifically in any publications.
Publishing research using ab3450? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"