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Product name
Mitochondrial Pyruvate dehydrogenase kinase 1 protein (Active)
See all Mitochondrial Pyruvate dehydrogenase kinase 1 products (6) ...
Protein description
Recombinant full length protein (Human)
Uniprot accession
Q15118
Protein length
408 amino acids
Expression host
E. coli
Properties
Purity
> 90% Purified via His tag
E.C. Number
2.7.11.2
Form
Liquid
Storage instructions
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Storage buffer
pH: 7.50
Constituents: 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.08% DTT, 0.02% EDTA, 0.05% Triton-X-100
Concentration
Concentration information loading...
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Integration of energy
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Energy transfer pathways >> Energy Metabolism
Metabolism >> Pathways and Processes >> Metabolic signaling pathways >> Carbohydrate metabolism
Cancer >> Cancer Metabolism >> Cellular metabolic process
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Integration of energy metabolism
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of carbohydrates
Signal Transduction >> Metabolism >> Energy Metabolism
Applications
Show applications key
Our Abpromise guarantee covers the use of ab110359 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
sELISA: Use at an assay dependent dilution.
FuncS: Use at an assay dependent concentration. See MitoSciences activity protocol.
Application notes
This peptide can be used with studies using ab110671.
Protein info
Function
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
Tissue specificity
Expressed predominantly in the heart.
Sequence similarities
Belongs to the PDK/BCKDK protein kinase family.
Contains 1 histidine kinase domain.
Cellular localization
Mitochondrion matrix.
Target information above from: UniProt accessionQ15118
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Protocols
References for Mitochondrial Pyruvate dehydrogenase kinase 1 protein (Active) (ab110359)
ab110359 has not yet been referenced specifically in any publications.
Publishing research using ab110359? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"