Overview

  • Product nameAnti-Monoamine Oxidase A antibody
    See all Monoamine Oxidase A primary antibodies
  • Description
    Goat polyclonal to Monoamine Oxidase A
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide:

    C-DAPWEAQHADKWDK

    , corresponding to Internal sequence amino acids 141-154 of Human Monoamine Oxidase A

  • Positive control
    • Human heart lysate and transfected HEK293 cells transiently expressing Monoamine Oxidase A.

Properties

Applications

Our Abpromise guarantee covers the use of ab40835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 60 kDa).

Target

  • FunctionCatalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
  • Tissue specificityHeart, liver, duodenum, blood vessels and kidney.
  • Involvement in diseaseDefects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
  • Sequence similaritiesBelongs to the flavin monoamine oxidase family.
  • Cellular localizationMitochondrion outer membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Amine oxidase [flavin containing] A antibody
    • Amine oxidase [flavin containing] A antibody
    • Amine oxidase [flavin-containing] A antibody
    • AOFA antibody
    • AOFA_HUMAN antibody
    • EC 1.4.3.4 antibody
    • flavin containingA antibody
    • HGNC:6833 antibody
    • MAO A antibody
    • MAO-A antibody
    • Maoa antibody
    • Monoamine oxidase A antibody
    • Monoamine oxidase type A antibody
    • RP1 201D17_B.2 antibody
    see all

Anti-Monoamine Oxidase A antibody images

  • All lanes : Anti-Monoamine Oxidase A antibody (ab40835) at 0.3 µg/ml

    Lane 1 : Human heart lysate
    Lane 2 : Human heart lysate with immunising peptide

    Lysates/proteins at 35 µg per lane.

    developed using the ECL technique

    Predicted band size : 60 kDa
    Observed band size : 70 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 85 kDa (possible non-specific binding).
  • Anti-Monoamine Oxidase A antibody (ab40835) at 0.3 µg/ml + lysate prepared from transfected HEK293 cells transiently expressing Monoamine Oxidase A

    Predicted band size : 60 kDa
    Observed band size : 60 kDa
    Additional bands at : 180 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Monoamine Oxidase A antibody (ab40835)

This product has been referenced in:
  • Kavazis AN  et al. Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins. Am J Physiol Heart Circ Physiol 297:H144-52 (2009). Read more (PubMed: 19429812) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"