Overview

  • Product nameAnti-Monoamine Oxidase A antibodySee all Monoamine Oxidase A primary antibodies ...
  • Description
    Mouse polyclonal to Monoamine Oxidase A
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human Monoamine Oxidase A protein (NP_000231.1)

  • Positive control
    • Human liver tissue lysate and Monoamine Oxidase A transfected 293T cell line lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab89921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa.

Target

  • FunctionCatalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
  • Tissue specificityHeart, liver, duodenum, blood vessels and kidney.
  • Involvement in diseaseDefects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
  • Sequence similaritiesBelongs to the flavin monoamine oxidase family.
  • Cellular localizationMitochondrion outer membrane.
  • Target information above from: UniProt accession P21397 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Amine oxidase [flavin containing] A antibody
    • Amine oxidase [flavin-containing] A antibody
    • AOFA antibody
    • AOFA_HUMAN antibody
    • EC 1.4.3.4 antibody
    • MAO A antibody
    • MAO-A antibody
    • Maoa antibody
    • Monoamine oxidase A antibody
    • Monoamine oxidase type A antibody
    see all

Anti-Monoamine Oxidase A antibody images

  • Anti-Monoamine Oxidase A antibody (ab89921) at 1 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : 60 kDa
    Observed band size : 60 kDa
  • All lanes : Anti-Monoamine Oxidase A antibody (ab89921) at 1 µg/ml

    Lane 1 : Monoamine Oxidase A transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 60 kDa
    Observed band size : 68 kDa (why is the actual band size different from the predicted?)

References for Anti-Monoamine Oxidase A antibody (ab89921)

This product has been referenced in:
  • Grouzmann E  et al. Monoamine oxidase a down-regulation contributes to high metanephrine concentration in pheochromocytoma. J Clin Endocrinol Metab 97:2773-81 (2012). Human . Read more (PubMed: 22569243) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"