Anti-Mre11 antibody [44B12] (ab119704)
- Product nameAnti-Mre11 antibody [44B12]See all Mre11 primary antibodies ...
- DescriptionMouse monoclonal [44B12] to Mre11
- Tested applicationsWB more details
- Species reactivityReacts with: Mouse, Rat, Human
Recombinant Human Mre11 with His tag, purified from E.coli.
- Positive controlHeLa, SK-N-MC, K562, A431, HepG2, SK-BR3 and Ramos cell lysates.
- Storage instructionsStore at -20°C. Stable for 12 months at -20°C
- Storage bufferPreservative: 0.03% Sodium azide
Constituents: 49% HEPES, 50% Glycerol, 0.88% Sodium chloride, 0.01% BSA
- Concentration information loading...
- PurityAmmonium Sulphate Precipitation
- Clonality Monoclonal
- Clone number44B12
- Light chain typekappa
- Research Areas
Our Abpromise guarantee covers the use of ab119704 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/2000. Predicted molecular weight: 81 kDa.|
- FunctionComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
- Involvement in diseaseDefects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course.
- Sequence similaritiesBelongs to the MRE11/RAD32 family.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationNucleus. Localizes to discrete nuclear foci after treatment with genotoxic agents.
- AT like disease antibodyAtaxia telangiectasia disorder like antibodyATLD antibody
- DNA recombination and repair protein antibodyDouble strand break repair protein MRE11A antibodyDouble-strand break repair protein MRE11A antibodyendo/exonuclease Mre11 antibodyHNGS1 antibodymeiotic recombination (S. cerevisiae) 11 homolog A antibodyMeiotic recombination 11 homolog 1 antibodymeiotic recombination 11 homolog A (S. cerevisiae) antibodyMeiotic recombination 11 homolog A antibodyMmMRE11A antibodyMre 11 antibodyMRE 11a antibodyMRE 11b antibodyMRE11 homolog 1 antibodyMRE11 homolog A antibodyMRE11 meiotic recombination 11 homolog A (S. cerevisiae) antibodyMRE11 meiotic recombination 11 homolog A antibodyMRE11_HUMAN antibodyMRE11A antibodyMRE11b antibodyOTTHUMP00000236830 antibodyOTTHUMP00000236831 antibodyOTTHUMP00000236832 antibodyOTTHUMP00000236833 antibody
Anti-Mre11 antibody [44B12] images
All lanes : Anti-Mre11 antibody [44B12] (ab119704) at 1/2000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : SK-N-MC cell lysate
Lane 3 : K562 cell lysate
Lane 4 : A431 cell lysate
Lane 5 : HepG2 cell lysate
Lane 6 : SK-BR3 cell lysate
Lane 7 : Ramos cell lysate
Predicted band size : 81 kDa
References for Anti-Mre11 antibody [44B12] (ab119704)
ab119704 has not yet been referenced specifically in any publications.