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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myelin Basic Protein antibody (ab49208)
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myelin Basic Protein antibody (ab49208)
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Product Name
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Myelin Basic Protein antibody
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See all Myelin Basic Protein antibodies (24)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Myelin Basic Protein
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Immunogen
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A peptide corresponding to an antigenic region within the guinea pig Myelin Basic Protein residue. This peptide was conjugated to carrier protein to enhance the immunological response
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Reacts with
(species key)
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Hu, Rat, Gpig
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Specificity
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Specificity of this product was demonstrated by immunohistochemistry where Myelin basic protein was detected in demyelinated nerve tissue from lesioned rat spinal cord. Discrete white matter in the brain of multiple system atrophy was also stained.
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Tested applications
(see key)
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ELISA, IHC-Fr
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Abreviews
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Application notes
(see key)
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Recommended dilutions
1 site ELISA: 1/5000.
IHC-Fr: 1/2000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic side of myelin.
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Research areas
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Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Glial
Neuroscience >> Cell Type Marker >> Glia marker >> Oligodendrocyte marker
Neuroscience >> Cell Adhesion Proteins >> Membrane Proteins
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Relevance
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The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Myelin Basic Protein antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Myelin Basic Protein antibody images, references, products related to ab49208 and other tools.
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Myelin Basic Protein antibody images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myelin Basic Protein antibody (ab49208)
Ab49208 (1:2000) staining of myelin basic protein on normal human brain by IHC (5µm thick paraffin-embedded section). Courtesy of Dr Wei-Ping Gai, The Flinders University of South Australia.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Myelin Basic Protein antibody (ab49208)
Ab49208 (1:2000) staining of myelin basic protein in human brain by IHC. Courtesy of Dr Wei-Ping Gai, The Flinders University of South Australia.
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Search PubMed (MEDLINE) for references to Myelin Basic Protein
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Myelin Basic Protein antibody - more information
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Customer reviews (feedback) regarding Myelin Basic Protein antibody |
Customer FAQs regarding Myelin Basic Protein antibody |
Protocols for Myelin Basic Protein antibody |
Price and availability of products related to Myelin Basic Protein antibody |
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Myelin Basic Protein antibody - related products:
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Myelin Basic Protein antibody - other tools:
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Contact Abcam with a Technical Enquiry about Myelin Basic Protein antibody |
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