Myelin Basic Protein antibody (ab49208)

Product Name 

Myelin Basic Protein antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to Myelin Basic Protein

Immunogen 

A peptide corresponding to an antigenic region within the guinea pig Myelin Basic Protein residue. This peptide was conjugated to carrier protein to enhance the immunological response

Reacts with 
(species key)

Hu, Rat, Gpig

Specificity 

Specificity of this product was demonstrated by immunohistochemistry where Myelin basic protein was detected in demyelinated nerve tissue from lesioned rat spinal cord. Discrete white matter in the brain of multiple system atrophy was also stained.

Tested applications 
(see key)

ELISA, IHC-Fr

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
1 site ELISA: 1/5000.
IHC-Fr: 1/2000.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic side of myelin.

Research areas 

Tags & Cell Markers >> Cell Type Markers >> Neuroscience Markers >> Glial
Neuroscience >> Cell Type Marker >> Glia marker >> Oligodendrocyte marker
Neuroscience >> Cell Adhesion Proteins >> Membrane Proteins

Relevance 

The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

Preservative: None
Constituents: Whole serum

Form 

Liquid

Concentration 

Concentration not determined - why is this?

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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