Anti-Myelin Protein Zero antibody (ab77354)
- Product nameAnti-Myelin Protein Zero antibodySee all Myelin Protein Zero primary antibodies ...
- DescriptionGoat polyclonal to Myelin Protein Zero
- Tested applicationsWB, ELISA more details
- Species reactivityReacts with: Rat
Predicted to work with: Mouse, Horse, Cow, Dog, Human, Pig
Synthetic peptide: DHSRSTKAVSEK, corresponding to internal sequence amino acids 224-235 of Human Myelin Protein Zero
- Positive controlRat Spinal Cord lysate.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesab77354 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab77354 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionCreation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
- Tissue specificityFound only in peripheral nervous system Schwann cells.
- Involvement in diseaseDefects in MPZ are the cause of Charcot-Marie-Tooth disease type 1B (CMT1B) [MIM:118200]. CMT1B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
Defects in MPZ are the cause of Charcot-Marie-Tooth disease type 2I (CMT2I) [MIM:607677]. CMT2I is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2I is characterized by late onset (range 47 to 60 years).
Defects in MPZ are the cause of Charcot-Marie-Tooth disease type 2J (CMT2J) [MIM:607736]. CMT2J is a form of Charcot-Marie-Tooth disease characterized by the association of axonal peripheral neuropathy with hearing loss and pupillary abnormalities such as Adie pupil. Inheritance is autosomal dominant.
Defects in MPZ are the cause of Adie pupil (ADIEP) [MIM:103100]. A stationary, benign disorder characterized by tonic, sluggishly reacting pupil and hypoactive or absent tendon reflexes. Adie pupil is a characteristic of Charcot-Marie-Tooth disease type 2J.
Defects in MPZ may be the cause of Charcot-Marie-Tooth disease dominant intermediate type D (CMTDID) [MIM:607791]. CMTDID is a form of Charcot-Marie-Tooth disease characterized by features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec.
Defects in MPZ are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.
Defects in MPZ are a cause of congenital hypomyelination neuropathy (CHN) [MIM:605253]. CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness, and very slow nerve conduction velocities.
Defects in MPZ are a cause of Roussy-Levy syndrome (ROULS) [MIM:180800]; also known as Roussy-Levy hereditary areflexic dystasia. This autosomal dominant disorder resembles Charcot-Marie-Tooth disease type 1 in that it presents with foot deformity, weakness and atrophy of distal limb muscles, especially the peronei, and absent tendon reflexes. The phenotype differs, however, in that it includes static tremor of the upper limbs and gait ataxia.
- Sequence similaritiesBelongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
modificationsN-glycosylated; contains sulfate-substituted glycan.
- Cellular localizationMembrane.
- Entrez Gene: 539462 Cow
- Entrez Gene: 488654 Dog
- Entrez Gene: 4359 Human
- Entrez Gene: 17528 Mouse
- Entrez Gene: 24564 Rat
- Omim: 159440 Human
- SwissProt: P10522 Cow
- SwissProt: P25189 Human
- SwissProt: P27573 Mouse
- SwissProt: Q5JZM5 Pig
- SwissProt: P06907 Rat
- Unigene: 93883 Human
- Unigene: 591486 Human
- Unigene: 9986 Mouse
- Unigene: 8997 Rat
- Charcot Marie Tooth neuropathy 1B antibodyCHM antibodyCMT1 antibody
- CMT1B antibodyCMT2I antibodyCMT2J antibodyCMT4E antibodyCMTDI3 antibodyDSS antibodyHMSNIB antibodyMPP antibodyMPZ antibodyMyelin P0 protein precursor antibodyMyelin peripheral protein antibodyMyelin protein P0 antibodyMyelin protein zero (Charcot Marie Tooth neuropathy 1B) antibodyMyelin protein zero antibodyMYP0_HUMAN antibodyP0 antibody
Anti-Myelin Protein Zero antibody images
Anti-Myelin Protein Zero antibody (ab77354) at 0.1 µg/ml + Rat Spinal Cord lysate (in RIPA buffer) at 35 µg
developed using the ECL technique
Predicted band size : 28 kDa
Observed band size : 28 kDa
References for Anti-Myelin Protein Zero antibody (ab77354)
ab77354 has not yet been referenced specifically in any publications.