Anti-Myeloperoxidase antibody [8F4] (ab16886)
Key features and details
- Mouse monoclonal [8F4] to Myeloperoxidase
- Suitable for: Flow Cyt (Intra)
- Reacts with: Mouse
- Isotype: IgG1
Overview
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Product name
Anti-Myeloperoxidase antibody [8F4]
See all Myeloperoxidase primary antibodies -
Description
Mouse monoclonal [8F4] to Myeloperoxidase -
Host species
Mouse -
Tested applications
Suitable for: Flow Cyt (Intra)more details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat -
Immunogen
Tissue, cells or virus corresponding to Mouse Myeloperoxidase.
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Positive control
- Neutrophils isolated from digested infarcts Flow Cyt (Intra): Wehi3BD+ cells.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purification notes
0.2 µm filtered -
Clonality
Monoclonal -
Clone number
8F4 -
Isotype
IgG1 -
Research areas
Associated products
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Assay kits
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab16886 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
Flow Cyt (Intra) |
1/10.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Notes |
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Flow Cyt (Intra)
1/10. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Target
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Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. -
Involvement in disease
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. -
Sequence similarities
Belongs to the peroxidase family. XPO subfamily. -
Cellular localization
Lysosome. - Information by UniProt
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Database links
- Entrez Gene: 17523 Mouse
- Entrez Gene: 303413 Rat
- SwissProt: P11247 Mouse
- Unigene: 4668 Mouse
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Alternative names
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 1.11.1.7 antibody
see all
Images
Protocols
Datasheets and documents
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Datasheet download
References (5)
ab16886 has been referenced in 5 publications.
- Díaz-Godínez C et al. New Insights on NETosis Induced by Entamoeba histolytica: Dependence on ROS from Amoebas and Extracellular MPO Activity. Antioxidants (Basel) 10:N/A (2021). PubMed: 34206992
- Roth Flach RJ et al. Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition. PLoS One 14:e0214150 (2019). PubMed: 30889221
- Chu TH et al. Hepatoma-derived growth factor participates in Helicobacter Pylori-induced neutrophils recruitment, gastritis and gastric carcinogenesis. Oncogene 38:6461-6477 (2019). PubMed: 31332288
- Lu SM et al. HIV-1 Tat-Induced Microgliosis and Synaptic Damage via Interactions between Peripheral and Central Myeloid Cells. PLoS One 6:e23915 (2011). IHC-FoFr ; Mouse . PubMed: 21912650
- Salguero Palacios R et al. Activation of hepatic stellate cells is associated with cytokine expression in thioacetamide-induced hepatic fibrosis in mice. Lab Invest 88:1192-203 (2008). IHC-Fr ; Mouse . PubMed: 18794850