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Anti-Myosin antibody [C5C.S2] (ab24648)

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Overview

Product name

Anti-Myosin antibody [C5C.S2]
See all Myosin products (8) ...

Description

Mouse monoclonal [C5C.S2] to Myosin

Specificity

This antibody recognizes most forms of myosin II, including smooth muscle myosin, skeletal muscle myosin and myosin from non muscle cells (platelets and fibroblasts).

Tested applications

IP, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Dog, Human

Immunogen

This antibody was raised against smooth muscle myosin.

Epitope

The epitope is the S2 region of myosin.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: None.
Constituents: Tissue culture supernatant.

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

C5C.S2

Isotype

IgM

Research areas

Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Motor Proteins >> Myosin

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Muscle contraction.

Sequence similarities

Contains 1 IQ domain.
Contains 1 myosin head-like domain.

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Cellular localization

Cytoplasm > myofibril. Thick filaments of the myofibrils.

Target information above from: UniProt accessionP12882 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • adult 1 antibody
  • skeletal muscle antibody
  • MGC133384 antibody
  • Myh 1 antibody
  • Myh1 antibody
  • MYH1_HUMAN antibody
  • MYH2 antibody
  • MYH3 antibody
  • MYH4 antibody
  • MYH6 antibody
  • MYHa antibody
  • MyHC 2X/D antibody
  • MyHC IIx/d antibody
  • MyHC-2x antibody
  • MyHC-IIx/d antibody
  • MYHSA1 antibody
  • MYL1 antibody
  • MYL2 antibody
  • MYL3 antibody
  • MYL5 antibody
  • MYL6 antibody
  • Myosin light chain 2 regulatory cardiac slow antibody
  • Myosin 1 antibody
  • Myosin heavy chain 1 antibody
  • Myosin heavy chain 1 skeletal muscle adult antibody
  • Myosin heavy chain 2 skeletal muscle adult antibody
  • Myosin heavy chain 2x antibody
  • Myosin heavy chain 3 skeletal muscle adult antibody
  • Myosin heavy chain 4 skeletal muscle adult antibody
  • Myosin heavy chain 6 skeletal muscle adult antibody
  • Myosin heavy chain antibody
  • Myosin heavy chain IIx/d antibody
  • Myosin heavy chain skeletal muscle adult 1 antibody
  • Myosin II antibody
  • Myosin light chain 1 alkali skeletal fast antibody
  • Myosin light chain 3 alkali ventricular skeletal slow antibody
  • Myosin light chain 4 alkali atrial embryonic antibody
  • Myosin light chain 5 regulatory antibody
  • Myosin light chain 6 alkali smooth muscle and non muscle antibody
  • Myosin-1 antibody
  • Myosin1 antibody
see all

Database links

see all

References for Anti-Myosin antibody [C5C.S2] (ab24648)

This product has been referenced in:

  • Peacock JG  et al. The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell 18:3860-72 (2007). ICC/IF; Mouse.Read more (PubMed: 17652459) »
  • Ito M  et al. Effect of monoclonal antibodies on the properties of smooth muscle myosin. Biochemistry 28:5567-72 (1989).Read more (PubMed: 2528373) »

See all 2 publications for this product

Publishing research using ab24648? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"