The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 122 kDa (predicted molecular weight: 122 kDa).
FunctionBinds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription.
Tissue specificityMostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes.
Predicted band size : 122 kDa Observed band size : 122 kDa Additional bands at : 140 kDa (possible post-translational modification).
References for Anti-Myt1 antibody (ab30997)
This product has been referenced in:
Yokoyama A et al. Identification of Myelin Transcription Factor 1 (MyT1) as a Subunit of the Neural Cell Type-specific Lysine-specific Demethylase 1 (LSD1) Complex. J Biol Chem289:18152-18162 (2014).
Read more (PubMed: 24828497) »
Kishimoto N et al. Interhemispheric asymmetry of olfactory input-dependent neuronal specification in the adult brain. Nat Neurosci16:884-8 (2013).
Read more (PubMed: 23685722) »