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Products:Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cadherins
Overview
Product name
Anti-N Cadherin antibody [8C11]
See all N Cadherin products (19) ...
Description
Mouse monoclonal [8C11] to N Cadherin
Tested applications
WB, ICC/IF, IPmore details
Cross reactivity
Reacts with
Human
Immunogen
Bacterial fusion protein corresponding to the extracellular domain of N-cadherin.
Positive control
A431 cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: PBS, 1mg/ml BSA
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
8C11
Isotype
IgG1
Research areas
Cancer >> Invasion/microenvironment >> ECM >> Cell adhesion >> Cadherins
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cadherins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19348 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlDetects a band of approximately 100 kDa.
ICC/IF: Use a concentration of 10 µg/ml
IP: Use at an assay dependent dilution.
Target
Function
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Sequence similarities
Contains 5 cadherin domains.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP19022
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CADH2_HUMAN antibody
- Cadherin 2 antibody
- Cadherin 2 N cadherin neuronal antibody
see all
Database links
- Entrez Gene: 1000 Human
- Omim: 114020 Human
- SwissProt: P19022 Human
- Unigene: 464829 Human
- Unigene: 606106 Human
References for Anti-N Cadherin antibody [8C11] (ab19348)
This product has been referenced in:
- Shintani Yet al. Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer. Ann Thorac Surg 92:1794-804; discussion 1804 (2011). ICC/IF; Human.Read more (PubMed: 22051275) »
- Ke XSet al. Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS ONE 3:e3368 (2008). WB, ICC/IF; Human.Read more (PubMed: 18852876) »
See all 3 publications for this product
Publishing research using ab19348? Please let us know so that we can cite the reference in this datasheet
![N Cadherin antibody [8C11] for WB in Xenopus laevis (19348)](/ps/datasheet/images/19/ab19348/N-Cadherin-Primary-antibodies-ab19348-1.jpg)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"