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Product Name
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N Cadherin antibody [8C11]
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See all N Cadherin antibodies (12)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [8C11] to N Cadherin
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Immunogen
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Bacterial fusion protein corresponding to the extracellular domain of N-cadherin.
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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ICC/IF, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ICC/IF: Use at a concentration of 10 µg/ml.
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml. Detects a band of approximately 100 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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A431 cell lysate
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Cellular localization
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Type I membrane protein
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Research areas
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Cancer >> Invasion/microenvironment >> ECM >> Cell adhesion >> Cadherins
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Signal Transduction >> Cytoskeleton / ECM >> Cell Adhesion >> Cadherins
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Relevance
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This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. N Cadherin has also been identified as a potential prognostic marker of a number of tumors.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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8C11
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Isotype
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IgG1
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Purity
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Protein G purified
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Storage buffer
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Preservative: 0.05% Sodium Azide
Constituents: PBS, 1mg/ml BSA Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this N Cadherin antibody [8C11] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for N Cadherin antibody [8C11] (ab19348)
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This product has been used in: (two most recent references)
Ke XS et al. Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS ONE 3:e3368 (2008). WB, ICC/IF; Human. PubMed: 18852876
This clone has been used in:
If you publish research using ab19348 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to N Cadherin
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N Cadherin antibody [8C11] - more information
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