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AbcamBiochemicals (Asc-026)

N-Desmethyl clozapine (Normethylclozapine) (ab120026)

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Overview

  • Product nameN-Desmethyl clozapine (Normethylclozapine)
  • Description
    Clozapine metabolite. M1 agonist. D2/D3 agonist.
  • Alternative names
    Normethylclozapine
  • Biological descriptionBrain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5HT1 and 5HT2.
  • Purity> 99%

    • Properties

  • Chemical name8-Chloro-11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • Molecular Weight312.80
  • Chemical structureChemical Structure
  • Molecular formulaC17H17ClN4
  • CAS Number6104-71-8
  • PubChem identifier2820
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESClc1ccc2Nc4ccccc4C(=Nc2c1)N3CCNCC3
  • Source

    Synthetic

  • Research Areas

    • References for N-Desmethyl clozapine (Normethylclozapine) (ab120026)

    This product has been referenced in:
    • Burstein ES  et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther 315:1278-87 (2005). Read more (PubMed: 16135699) »
    • Sur C  et al. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 100:13674-9 (2003). Read more (PubMed: 14595031) »
    • Fox S & Brotchie J Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur J Pharmacol 301:27-30 (1996). Read more (PubMed: 8773443) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"