Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Protein Phosphorylation >> Ser / Thr Kinases >> Other Kinases
Overview
Product name
Anti-NAK antibody
See all NAK products (10) ...
Description
Rabbit polyclonal to NAK
Specificity
This antibody has no cross response to IKK alpha, IKK beta, IKK gamma, or IKK epsilon.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Predicted to work with
Pig
Immunogen
Synthetic peptide: ERFGSLTMDGGLRNVD, corresponding to internal sequence amino acids 712-727 of Human NAK
ERFGSLTMDG GLRNVD
Positive control
MOLT4 whole cell lysate.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Show applications key
Our Abpromise guarantee covers the use of ab62871 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml.Predicted molecular weight: 84 kDa.
Target
Function
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.
Tissue specificity
Ubiquitous with higher expression in testis.
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ9UHD2
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- EC 2.7.11.1 antibody
- FLJ11330 antibody
- NAK antibody
see all
Database links
- Entrez Gene: 29110 Human
- Entrez Gene: 56480 Mouse
- Entrez Gene: 299827 Rat
- Omim: 604834 Human
- SwissProt: Q9UHD2 Human
- SwissProt: Q9WUN2 Mouse
- Unigene: 505874 Human
- Unigene: 34580 Mouse
see all
References for Anti-NAK antibody (ab62871)
ab62871 has not yet been referenced specifically in any publications.
Publishing research using ab62871? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"