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Products:Cell Biology >> Cell Cycle >> Cell Division >> Cytokinesis
Overview
Product name
Anti-NAT10 antibody
See all NAT10 products (2) ...
Description
Goat polyclonal to NAT10
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat, Cow, Dog
Immunogen
Synthetic peptide: C-KSDKKRKLEAKQ, corresponding to internal sequence (near the C terminal) amino acids 989 - 1000 of Human NAT10 (NP_078938.1)
KSDKKRKLEA KQ
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, Tris saline, pH 7.3
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
ab78600 is purified by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> DNA Damage Response >> Other
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microtubules >> Tubulin
Epigenetics and Nuclear Signaling >> Chromosome Structure >> Telomeres
Cell Biology >> Cell Cycle >> Cell Division >> Cytokinesis
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAT10 antibody (ab78600)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab78600 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 3 - 6 µg/ml.
Target
Function
Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.
Sequence similarities
Belongs to the UPF0202 family.
Contains 1 N-acetyltransferase domain.
Cellular localization
Nucleus > nucleolus. Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase.
Target information above from: UniProt accessionQ9H0A0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- ALP antibody
- DKFZp434C116 antibody
- FLJ10774 antibody
see all
Database links
- Entrez Gene: 515001 Cow
- Entrez Gene: 483431 Dog
- Entrez Gene: 55226 Human
- Entrez Gene: 98956 Mouse
- Omim: 609221 Human
- SwissProt: Q9H0A0 Human
- SwissProt: Q8K224 Mouse
- Unigene: 9272 Cow
see all
Anti-NAT10 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NAT10 antibody (ab78600)
ab78600 at 3.8 µg/ml staining NAT10 in Human colon by Immunohistochemsitry (Formalin/PFA-fixed paraffin-embedded sections). Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
References for Anti-NAT10 antibody (ab78600)
ab78600 has not yet been referenced specifically in any publications.
Publishing research using ab78600? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"