Anti-NCKIPSD antibody [2614C1a] (ab58676)

Overview

  • Product nameAnti-NCKIPSD antibody [2614C1a]
    See all NCKIPSD primary antibodies
  • Description
    Mouse monoclonal [2614C1a] to NCKIPSD
  • Tested applicationsWB, Dot Blotmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab58676 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent dilution. Predicted molecular weight: 79 kDa.
Dot Blot Use at an assay dependent dilution.

Target

  • FunctionHas an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion.
  • Tissue specificityHighest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen.
  • Involvement in diseaseNote=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with MLL.
  • Sequence similaritiesContains 1 SH3 domain.
  • Cellular localizationNucleus. Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes.
  • Information by UniProt
  • Database links
  • Alternative names
    • 54 kDa VacA-interacting protein antibody
    • 54 kDa vimentin-interacting protein antibody
    • 90 kDa SH3 protein interacting with Nck antibody
    • AF3p21 antibody
    • dia interacting protein antibody
    • Dia-interacting protein 1 antibody
    • Diaphanous protein-interacting protein antibody
    • DIP antibody
    • DIP-1 antibody
    • DIP1 antibody
    • NCK interacting protein with SH3 domain antibody
    • NCK-interacting protein with SH3 domain antibody
    • Nckipsd antibody
    • ORF1 antibody
    • SH3 adapter protein SPIN90 antibody
    • SH3 protein interacting with Nck 90 kDa antibody
    • SPIN90 antibody
    • SPN90_HUMAN antibody
    • VIP54 antibody
    • WASLBP antibody
    • WASP-interacting SH3-domain protein antibody
    • WISH antibody
    • wiskott- Aldrich syndrome protein-interacting protein antibody
    • Wiskott-Aldrich syndrome protein-interacting protein antibody
    see all

Anti-NCKIPSD antibody [2614C1a] images

References for Anti-NCKIPSD antibody [2614C1a] (ab58676)

ab58676 has not yet been referenced specifically in any publications.

Product Wall

Thank you for reply, and I apologize again for the variability in the results with this antibody. I am sending a free of charge replacement vial on the order ***. We currently are out of stock of ab58676, so the expected delivery date is December 14. A...

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Thank you for contacting us and letting us know about the problem with this antibody. I am sorry to hear that this new lot is not working as expected. We do guarantee all our products to worked in tested species and applications for up to 6 months afte...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"