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Overview

  • Product nameNDUFAF4 protein (His tag)
  • Protein descriptionRecombinant full length Human NDUFAF4 (amino acids 1-175) with N terminal His tag; 198 aa, 22.7kDa inclusive of tag. (NP_054884).
  • Uniprot accessionQ9P032
  • Molecular weight22.700kDa inclusive of tags
  • Protein length175 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 85 % by SDS-PAGE
  • Purification notesab134610 was purified using conventional chromatography techniques.
  • Mass spectrometryMALDI-TOF
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 10% Glycerol, 0.88% Sodium chloride
  • Concentration information loading...
  • Sequence notesMGSSHHHHHH SSGLVPRGSH MGSMGALVIR GIRNFNLENR AEREISKMKP SVAPRHPSTN SLLREQISLY PEVKGEIARK DEKLLSFLKD VYVDSKDPVS SLQVKAAETC QEPKEFRLPK DHHFDMINIK SIPKGKISIV EALTLLNNHK LFPETWTAEK IMQEYQLEQK DVNSLLKYFV TFEVEIFPPE DKKAIRSK
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab134610 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    MS MS: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        C6orf66Hormone-regulated proliferation-associated protein of 20 kDaHRPAP20
        HSPC125My013NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4NDUF4_HUMANNdufaf4
      see all
  • FunctionInvolved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.
  • Involvement in diseaseDefects in NDUFAF4 are a cause of mitochondrial complex I deficiency (MT-C1D) [MIM:252010]. A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease.
  • Sequence similaritiesBelongs to the NDUFAF4 family.
  • Post-translational
    modifications    Phosphorylated on serine. Prolactin stimulate serine phosphorylation.
  • Cellular localizationMitochondrion.

    • Target information above from: UniProt accession Q9P032 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    NDUFAF4 protein (His tag) images

    • SDS-PAGE - NDUFAF4 protein (His tag) (ab134610)
      SDS-PAGE - NDUFAF4 protein (His tag) (ab134610)
      15% SDS-PAGE analysis of ab134610 (3µg).

    References for NDUFAF4 protein (His tag) (ab134610)

    ab134610 has not yet been referenced specifically in any publications.

    Publishing research using ab134610 ? Please let us know so that we can cite the reference in this datasheet

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