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Overview
Product name
NEDD4-2 peptide
Protein description
Synthetic peptide derived from within residues 100 - 200 of Human NEDD4-2.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab73386 - NEDD4-2 antibody.
Protein length
975 amino acids
Properties
Purity
70 - 90% by HPLC
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
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Applications
Application notes
This peptide can be used with studies using ab73386.
Protein info
Relevance
E3 ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. Furthermore, it promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5, and promotes the ubiquitination and degradation of SGK.
Cellular localization
Cytoplasmic
References for NEDD4-2 peptide (ab73385)
ab73385 has not yet been referenced specifically in any publications.
Publishing research using ab73385? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"