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Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Base Excision Repair
Overview
Product name
Anti-NEIL1 antibody
See all NEIL1 products (3) ...
Description
Rabbit polyclonal to NEIL1
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full-length human NEIL1 protein
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 20% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Base Excision Repair
Applications
Show applications key
Our Abpromise guarantee covers the use of ab21337 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Predicted molecular weight: 44 kDa.
Target
Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.
Tissue specificity
Ubiquitous.
Sequence similarities
Belongs to the FPG family.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ96FI4
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA (apurinic or apyrimidinic site) lyase Neil1 antibody
- DNA glycosylase/AP lyase Neil 1 antibody
- DNA glycosylase/AP lyase Neil1 antibody
see all
Database links
- Entrez Gene: 79661 Human
- Omim: 608844 Human
- SwissProt: Q96FI4 Human
- Unigene: 512732 Human
References for Anti-NEIL1 antibody (ab21337)
This product has been referenced in:
- Odell IDet al. Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1. DNA Repair (Amst) 9:134-43 (2010).Read more (PubMed: 20005182) »
- Suzuki Tet al. Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine. DNA Repair (Amst) 9:542-50 (2010).Read more (PubMed: 20197241) »
See all 3 publications for this product
Publishing research using ab21337? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"