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Product name
Anti-NEIL2 antibody
See all NEIL2 products (4) ...
Description
Mouse monoclonal to NEIL2
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Recombinant full length protein, corresponding to amino acids 1-333 of Human NEIL2
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
PBS, pH 7.2
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Isotype
IgG1
Light chain type
kappa
Research areas
Epigenetics and Nuclear Signaling >> DNA / RNA >> DNA Damage & Repair >> Base Excision Repair
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Western blot - NEIL2 antibody (ab56577)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Tissue specificity
Detected in testis, skeletal muscle, heart, brain, placenta, lung, pancreas, kidney and liver.
Sequence similarities
Belongs to the FPG family.
Contains 1 FPG-type zinc finger.
Domain
The zinc-finger domain is important for DNA binding.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ969S2
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DNA glycosylase/AP lyase Neil2 antibody
- DNA-(apurinic or apyrimidinic site) lyase Neil2 antibody
- Endonuclease 8-like 2 antibody
see all
Database links
- Entrez Gene: 252969 Human
- Omim: 608933 Human
- SwissProt: Q969S2 Human
- Unigene: 293818 Human
Anti-NEIL2 antibody images:
Western blot - NEIL2 antibody (ab56577)
Western blot against tagged recombinant protein immunogen using ab56577 NEIL2 antibody at 1ug/ml. Predicted band size of immunogen is 63 kDa
References for Anti-NEIL2 antibody (ab56577)
ab56577 has not yet been referenced specifically in any publications.
Publishing research using ab56577? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"