Anti-NELFe antibody (ab84986)

Overview

• Product nameAnti-NELFe antibodySee all NELFe primary antibodies ...
• Description
  Rabbit polyclonal to NELFe
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide, corresponding to a region between residue 330 and 380 of human NELFe (NP_002895.3)

• Positive controlHuman Breast Carcinoma, human Placenta

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 0.1% BSA, Tris buffered saline
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Elongation factors

Applications

Target

• FunctionEssential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.
• Tissue specificityWidely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
• Sequence similaritiesBelongs to the RRM NELF-E family.
  Contains 1 RRM (RNA recognition motif) domain.
• DomainThe RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation.
• Post-translational
  modificationsSumoylated.
• Cellular localizationNucleus.

Target information above from: UniProt accession P18615 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7936 Human
  • Omim: 154040 Human
  • SwissProt: Q5JP74 Human
  • SwissProt: Q5JP75 Human
  • SwissProt: P18615 Human
  • Unigene: 423935 Human

• Alternative names
  Major histocompatibility complex gene RD antibodyNegative elongation factor E antibodyNegative elongation factor polypeptide E antibody

  NELF e antibodyNELF-E antibodyNelfe antibodyNELFE_HUMAN antibodyNuclear protein antibodyRD antibodyRD protein antibodyRD RNA binding protein antibodyRDBP antibodyRDP antibodyRNA-binding protein RD antibody

  see all

Anti-NELFe antibody images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NELFe antibody (ab84986)
  ab84986 at 1/250 dilution staining NELFe in human breast carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NELFe antibody (ab84986)
  ab84986 at 1/250 dilution staining NELFe in human placenta by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.