NFAT1 peptide (ab4905)
Our Abpromise guarantee covers the use of ab4905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Blocking||BL: Use at an assay dependent concentration.|
- AI607462cytoplasmic 2KIAA0611
- NF ATpNF-ATc2NF-ATpNFAC2_HUMANNFAT 1NFAT pre existing subunitNFAT pre-existing subunitNFAT transcription complex, preexisting componentNFAT1NFAT1-DNFATc2NFATc2NFATpNFATpNuclear factor of activated T cells cytoplasmic 2Nuclear factor of activated T cells cytoplasmic 2Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2Nuclear factor of activated T cells pre-existing componentNuclear factor of activated T cells pre-existing componentNuclear factor of activated T-cellsT cell transcription factor NFAT 1T cell transcription factor NFAT 1T-cell transcription factor NFAT1
modificationsIn resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.
References for NFAT1 peptide (ab4905)
ab4905 has not yet been referenced specifically in any publications.