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Overview

  • Product nameNFAT1 peptideSee all NFAT1 proteins and peptides ...

    • Properties

  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Concentration information loading...
  • Sequence notesA 19 amino acid synthetic peptide whose sequence corresponds to residues 51-69 of mouse NFAT 1. The sequence of this peptide is (amino to carboxy terminus): A(51)ISSPSGLAYPDDVLDYGL(69).
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab4905 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Blocking BL: Use at an assay dependent concentration.
  • Application notesThis peptide can be used with studies using ab2722.

    • Protein info

    • Alternative names
        AI607462cytoplasmic 2KIAA0611
        NF ATpNF-ATc2NF-ATpNFAC2_HUMANNFAT 1NFAT pre existing subunitNFAT pre-existing subunitNFAT transcription complex, preexisting componentNFAT1NFAT1-DNFATc2NFATc2NFATpNFATpNuclear factor of activated T cells cytoplasmic 2Nuclear factor of activated T cells cytoplasmic 2Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2Nuclear factor of activated T cells pre-existing componentNuclear factor of activated T cells pre-existing componentNuclear factor of activated T-cellsT cell transcription factor NFAT 1T cell transcription factor NFAT 1T-cell transcription factor NFAT1
      see all
  • FunctionPlays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF.
  • Tissue specificityExpressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas.
  • Sequence similaritiesContains 1 RHD (Rel-like) domain.
  • DomainRel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors.
  • Post-translational
    modifications    In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-363 region. Upon cell stimulation, all these sites except Ser-243 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, Ser-53 or Ser-56 is phosphorylated; which is required for full transcriptional activity.
  • Cellular localizationCytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

    • Target information above from: UniProt accession Q13469 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for NFAT1 peptide (ab4905)

    ab4905 has not yet been referenced specifically in any publications.

    Publishing research using ab4905 ? Please let us know so that we can cite the reference in this datasheet

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    I haven't used this peptide yet, but I would like to know what the expected molecular weight of this peptide is. I need to be able to differentiate this peptide from other protein using mass spectroscopy.

    The molecular weight of this peptide is ~2.4 kDa. Let me know if you have any additional questions.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"