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Products:Neuroscience >> Neurotransmission >> Calcium Signaling >> Calcium Channels >> IP3R
Overview
Product name
Anti-NIR1 antibody
See all NIR1 products (4) ...
Description
Rabbit polyclonal to NIR1
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse
Immunogen
Synthetic peptide, corresponding to a region within amino acids 912-974 of Human NIR1 (NP_112497)
Positive control
293T and Raji whole cell lysates
Properties
Form
Liquid
Storage instructions
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
-
Western blot - NIR1 antibody (ab96661)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab96661 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/3000.Predicted molecular weight: 107 kDa.
Target
Function
Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ions.
Tissue specificity
Detected in brain and spleen, and at low levels in ovary.
Involvement in disease
Defects in PITPNM3 are the cause of cone-rod dystrophy type 5 (CORD5) [MIM:600977]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.
Sequence similarities
Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.
Contains 1 DDHD domain.
Cellular localization
Endomembrane system.
Target information above from: UniProt accessionQ9BZ71
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- membrane-associated 3 antibody
- CORD5 antibody
- Membrane associated phosphatidylinositol transfer protein 3 antibody
see all
Database links
- Entrez Gene: 83394 Human
- Entrez Gene: 327958 Mouse
- Omim: 608921 Human
- SwissProt: Q9BZ71 Human
- SwissProt: Q3UHE1 Mouse
- Unigene: 183983 Human
- Unigene: 351793 Mouse
Anti-NIR1 antibody images:
Western blot - NIR1 antibody (ab96661)
All lanes : Anti-NIR1 antibody (ab96661) at 1/1500 dilution
Lane 1 : 293T whole cell lysate
Lane 2 : Raji whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size : 107 kDa
7.5% SDS PAGE
References for Anti-NIR1 antibody (ab96661)
ab96661 has not yet been referenced specifically in any publications.
Publishing research using ab96661? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"