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Product name
Anti-NKIRAS1 antibody [184C278]
See all NKIRAS1 products (2) ...
Description
Mouse monoclonal [184C278] to NKIRAS1
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Mouse, Rat
Immunogen
Synthetic peptide: RVELLKKEIDKFKDKKEV, corresponding to amino acids 96-113 of Human NKIRAS1.
RVELLKKEIDKFKDKKEV
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
184C278
Isotype
IgG1
Research areas
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> NFkB Pathway
Applications
Show applications key
Our Abpromise guarantee covers the use of ab13666 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 23 kDa.
Target
Function
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Tissue specificity
Widely expressed.
Sequence similarities
Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
Domain
In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Leu residues, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
Cellular localization
Cytoplasm.
Target information above from: UniProt accessionQ9NYS0
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 2400004O09Rik antibody
- I kappa B interacting Ras like protein 1 antibody
- I-kappa-B-interacting Ras-like protein 1 antibody
see all
Database links
- Entrez Gene: 28512 Human
- Entrez Gene: 69721 Mouse
- Entrez Gene: 305751 Rat
- Omim: 604496 Human
- SwissProt: Q9NYS0 Human
- SwissProt: Q8CEC5 Mouse
- Unigene: 173202 Human
- Unigene: 25648 Mouse
References for Anti-NKIRAS1 antibody [184C278] (ab13666)
ab13666 has not yet been referenced specifically in any publications.
Publishing research using ab13666? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"