Anti-NKIRAS2 antibody (ab129577)

Overview

• Product nameAnti-NKIRAS2 antibodySee all NKIRAS2 primary antibodies ...
• Description
  Rabbit polyclonal to NKIRAS2
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 35-64 of Human NKIRAS2 (NP_060065.2).

• Positive controlU937 cell line lysates.

Properties

• FormLiquid
• Storage instructionsStore at 2-8°C for up to 6 months. For long term storage store at -20°C.
• Storage bufferPreservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab129577 is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • NFkB Pathway

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • NFkB pathway

Applications

Target

• FunctionAtypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
• Tissue specificityWidely expressed.
• Sequence similaritiesBelongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.
• DomainIn contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.
• Cellular localizationCytoplasm.

Target information above from: UniProt accession Q9NYR9 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 28511 Human
  • Omim: 604497 Human
  • SwissProt: Q9NYR9 Human
  • Unigene: 632252 Human

• Alternative names
  DKFZP434N1526 antibodyI kappa B interacting Ras like protein 2 antibodyI-kappa-B-interacting Ras-like protein 2 antibody

  Kappa B Ras protein 2 antibodyKappa B-Ras protein 2 antibodyKappaB Ras2 antibodyKappaB-Ras2 antibodyKBRAS 2 antibodyKBRAS2 antibodyKBRS2_HUMAN antibodyMGC74742 antibodyNF kappa B inhibitor interacting Ras like protein 2 antibodyNF-kappa-B inhibitor-interacting Ras-like protein 2 antibodyNFKB inhibitor interacting Ras like 2 antibodyNFKB inhibitor interacting Ras like protein 2 antibodyNKIRAS 2 antibodyNKIRAS2 antibody

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Anti-NKIRAS2 antibody images

• 

  Western blot - Anti-NKIRAS2 antibody (ab129577)
  Anti-NKIRAS2 antibody (ab129577) at 1/100 dilution + U937 cell line lysates at 35 µg
  developed using the ECL technique
  
  Predicted band size : 22 kDa