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Overview

  • Product nameNMNAT2 protein (Active)See all NMNAT2 proteins and peptides ...
  • Protein descriptionRecombinant full length Human NMNAT2 (amino acids 2-307) with an N terminal His tag; MWt 35 kDa (by SDS-PAGE) (UniProt Q9BZQ4).
  • Uniprot accessionQ9BZQ4
  • Molecular weight35kDa inclusive of tags
  • Protein length306 amino acids
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesab109152 is 0.2µm filtered
  • Biological activityConverts NMN to NAD+.
  • E.C. Number2.7.7.1
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    Constituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2
  • Concentration information loading...
  • Additional notesWorking aliquots are stable for up to 3 months when stored at -20°C.
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab109152 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies FuncS: Use at an assay dependent dilution.
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        C1orf15KIAA0479MGC2756
        NaMN adenylyltransferase 2Nicotinamide mononucleotide adenylyltransferase 2Nicotinamide nucleotide adenylyltransferase 2Nicotinate-nucleotide adenylyltransferase 2NMN adenylyltransferase 2NMNA2_HUMANNMNAT 2Nmnat2PNAT 2PNAT2Pyridine nucleotide adenylyltransferase 2
      see all
  • FunctionCatalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannnot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+).
  • Tissue specificityHighly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
  • PathwayCofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
  • Sequence similaritiesBelongs to the eukaryotic NMN adenylyltransferase family.
  • Cellular localizationCytoplasm. Golgi apparatus.

    • Target information above from: UniProt accession Q9BZQ4 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for NMNAT2 protein (Active) (ab109152)

    ab109152 has not yet been referenced specifically in any publications.

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