Anti-NMNAT3 antibody (ab123807)

Overview

• Product nameAnti-NMNAT3 antibodySee all NMNAT3 primary antibodies ...
• Description
  Goat polyclonal to NMNAT3
• Specificityab123807 is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1).
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Horse, Dog
• Immunogen

  Synthetic peptide: C-QHNIHLAKEPVQNE, corresponding to internal sequence amino acids 149-162 of Human NMNAT3 isoform 2 and 186-199 of Human NMNAT3 isoform 1 (NP_001186976.1. NP_835471.1).

  Run BLAST with Run BLAST with
• Positive controlHuman kidney lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferpH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: 99% Tris buffered saline, 0.5% BSA
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab123807 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

Applications

Target

• FunctionCatalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
• Tissue specificityExpressed in lung and spleen with lower levels in placenta and kidney.
• PathwayCofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
• Sequence similaritiesBelongs to the eukaryotic NMN adenylyltransferase family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession Q96T66 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 477091 Dog
  • Entrez Gene: 349565 Human
  • Entrez Gene: 349565 Human
  • Entrez Gene: 349565 Human
  • Omim: 608702 Human
  • SwissProt: Q96T66 Human
  • SwissProt: Q96T66 Human
  • SwissProt: Q96T66 Human

  • Unigene: 208673 Human

  see all

• Alternative names
  NaMN adenylyltransferase 3 antibodyNicotinamide mononucleotide adenylyltransferase 3 antibodyNicotinamide nucleotide adenylyltransferase 3 antibody

  Nicotinate-nucleotide adenylyltransferase 3 antibodyNMN adenylyltransferase 3 antibodyNMNA3_HUMAN antibodyNMNAT 3 antibodyNmnat3 antibodyPNAT 3 antibodyPNAT-3 antibodyPNAT3 antibodyPyridine nucleotide adenylyltransferase 3 antibody

  see all

Anti-NMNAT3 antibody images

• 

  Western blot - Anti-NMNAT3 antibody (ab123807)
  Anti-NMNAT3 antibody (ab123807) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µg
  developed using the ECL technique
  
  Predicted band size : 24 kDa