Overview

  • Product nameAnti-NMNAT3 antibodySee all NMNAT3 primary antibodies ...
  • Description
    Goat polyclonal to NMNAT3
  • Specificityab123807 is expected to recognize both reported isoforms (NP_835471.1; NP_001186976.1).
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Dog
  • Immunogen

    Synthetic peptide:

    C-QHNIHLAKEPVQNE

    , corresponding to internal sequence amino acids 149-162 of Human NMNAT3 isoform 2 and 186-199 of Human NMNAT3 isoform 1 (NP_001186976.1. NP_835471.1).

  • Positive control
    • Human kidney lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab123807 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 26 kDa (predicted molecular weight: 24 kDa).

Target

  • FunctionCatalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury.
  • Tissue specificityExpressed in lung and spleen with lower levels in placenta and kidney.
  • PathwayCofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
  • Sequence similaritiesBelongs to the eukaryotic NMN adenylyltransferase family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • NaMN adenylyltransferase 3 antibody
    • Nicotinamide mononucleotide adenylyltransferase 3 antibody
    • Nicotinamide nucleotide adenylyltransferase 3 antibody
    • Nicotinate-nucleotide adenylyltransferase 3 antibody
    • NMN adenylyltransferase 3 antibody
    • NMNA3_HUMAN antibody
    • NMNAT 3 antibody
    • Nmnat3 antibody
    • PNAT 3 antibody
    • PNAT-3 antibody
    • PNAT3 antibody
    • Pyridine nucleotide adenylyltransferase 3 antibody
    see all

Anti-NMNAT3 antibody images

  • Anti-NMNAT3 antibody (ab123807) at 0.1 µg/ml + Human Kidney lysate (in RIPA buffer) at 35 µg
    developed using the ECL technique

    Predicted band size : 24 kDa

References for Anti-NMNAT3 antibody (ab123807)

ab123807 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"