Overview

  • Product nameAnti-NORE1 antibodySee all NORE1 primary antibodies ...
  • Description
    Rabbit polyclonal to NORE1
  • SpecificityAb33292 recognises NORE1 protein.
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    DNPQKFALFKRIHKDGQ

    , corresponding to amino acids 313-329 of NORE1. This sequence is located in the RA domain of NORE1.

Properties

Applications

Our Abpromise guarantee covers the use of ab33292 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 44 kDa.

Target

  • FunctionPotential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
  • Tissue specificityWidely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
  • Sequence similaritiesContains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-associating domain.
    Contains 1 SARAH domain.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.
  • Information by UniProt
  • Database links
  • Alternative names
    • Maxp 1 antibody
    • MAXP1 antibody
    • MGC10823 antibody
    • MGC17344 antibody
    • New ras effector 1 antibody
    • NORE 1 antibody
    • NORE1A antibody
    • NORE1B antibody
    • Novel Ras effector 1 antibody
    • RAP1 Binding Protein antibody
    • RAPL antibody
    • Ras association (RalGDS/AF 6) domain family 5 antibody
    • Ras association (RalGDS/AF 6) domain family member 5 antibody
    • Ras Association (RalGDS/AF6) Domain Family 5 antibody
    • Ras association domain containing family protein 5 antibody
    • Ras association domain-containing protein 5 antibody
    • Ras effector like protein antibody
    • RASF5_HUMAN antibody
    • RASSF 3 antibody
    • RASSF 5 antibody
    • RASSF3 antibody
    • RASSF5 antibody
    • Regulator for cell adhesion and polarization enriched in lymphoid tissue antibody
    • Regulator for cell adhesion and polarization enriched in lymphoid tissues antibody
    • Tumor suppressor RASSF3 antibody
    see all

References for Anti-NORE1 antibody (ab33292)

ab33292 has not yet been referenced specifically in any publications.

Product Wall

Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten. Wie gerade besprochen, wissen wir nicht mit Sicherheit, welche Isoformen der NORE1-Antikörper ab33292 erkennt, und auch haben wir noch keine Abbildung. Falls Sie uns eine Abbild...

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Thank you for your enquiry. With reference to the three NORE1 antibodies that we sell I have further information relating to the likely cross reactivity shown by two of the antibodies; ab16757: The sequence used to raise this antibody is shared b...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"