Anti-NORE1 antibody (ab33292)

Overview

• Product nameAnti-NORE1 antibodySee all NORE1 primary antibodies ...
• Description
  Rabbit polyclonal to NORE1
• SpecificityAb33292 recognises NORE1 protein.
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide: DNPQKFALFKRIHKDGQ, corresponding to amino acids 313-329 of NORE1. This sequence is located in the RA domain of NORE1.

  Run BLAST with Run BLAST with

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesAb33292 is affinity purified.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

  • Cancer
  • Signal transduction
  • G protein signaling
  • Small G proteins
  • Ras family

  • Signal Transduction
  • Signaling Pathway
  • G Protein Signaling
  • Small G Proteins
  • Ras Family

  • Cell Biology
  • Apoptosis
  • Nucleus
  • Other

Applications

Target

• FunctionPotential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
• Tissue specificityWidely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
• Sequence similaritiesContains 1 phorbol-ester/DAG-type zinc finger.
  Contains 1 Ras-associating domain.
  Contains 1 SARAH domain.
• Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.

Target information above from: UniProt accession Q8WWW0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 83593 Human
  • Entrez Gene: 54354 Mouse
  • Entrez Gene: 54355 Rat
  • Omim: 607020 Human
  • SwissProt: Q8WWW0 Human
  • SwissProt: Q5EBH1 Mouse
  • SwissProt: O35141 Rat
  • Unigene: 497579 Human

  • Unigene: 248291 Mouse
  • Unigene: 36106 Rat

  see all

• Alternative names
  Maxp 1 antibodyMAXP1 antibodyMGC10823 antibody

  MGC17344 antibodyNew ras effector 1 antibodyNORE 1 antibodyNORE1A antibodyNORE1B antibodyNovel Ras effector 1 antibodyRAP1 Binding Protein antibodyRAPL antibodyRas association (RalGDS/AF 6) domain family 5 antibodyRas association (RalGDS/AF 6) domain family member 5 antibodyRas Association (RalGDS/AF6) Domain Family 5 antibodyRas association domain containing family protein 5 antibodyRas association domain-containing protein 5 antibodyRas effector like protein antibodyRASF5_HUMAN antibodyRASSF 3 antibodyRASSF 5 antibodyRASSF3 antibodyRASSF5 antibodyRegulator for cell adhesion and polarization enriched in lymphoid tissue antibodyRegulator for cell adhesion and polarization enriched in lymphoid tissues antibodyTumor suppressor RASSF3 antibody

  see all