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Product Name
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NR0B1 / Dax1 antibody [H7431]
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See all NR0B1 / Dax1 antibodies (10)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [H7431] to NR0B1 / Dax1
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Immunogen
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Baculovirus-expressed recombinant fragment: MAGEDHPWQG SILYNLLMSA KQKHASQEER EVRLGAQCWG CACGAQPVLG GERLSGGQAR , corresponding to amino acids 1-80 of Human NR0B1 / Dax1.
BLAST 'MAGEDHPWQG SILYNLLMSA KQKHASQEER EVRLGAQCWG CACGAQPVLG GERLSGGQAR ' with  or 
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Reacts with
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Hu
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Predicted to react
(species key)
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Rat
(Due to sequence homology)
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at a concentration of 0.6 µg/ml. (A450=0.2).
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Nuclear
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Research areas
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Developmental Biology >> Reproduction >> Placental development
Developmental Biology >> Reproduction >> Sex determination
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Orphan Nuclear Receptors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Retinoic & Retinoid
Neuroscience >> Endocrine system >> hypothalamic pituitary adrenal axis
Neuroscience >> Endocrine system >> Gonadotrophic axis
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Relevance
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NR0B1 is a receptor that may be a component of a cascade required for development of steroidogenic tissues. It acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor.
It interacts with COPS2.
Defects in NR0B1 are the cause of X-linked adrenal hypoplasia congenital (AHC). AHC is a developmental disorder of the adrenal gland that results in profound hormonal deficiencies and is lethal if untreated. It is characterized by the absence of the permanent zone of the adrenal cortex and by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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H7431
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Isotype
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IgG2a
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Storage buffer
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Physiological Saline
Preservative: 0.1% Sodium Azide
Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purified from ascites by ammonium sulfate fractionation
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this NR0B1 / Dax1 antibody [H7431] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to NR0B1 / Dax1
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NR0B1 / Dax1 antibody [H7431] - more information
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