|
|
|
|
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NR0B1 / Dax1 antibody (ab61435)
(enlarge)
|
|
|
|
|
Product Name
|
NR0B1 / Dax1 antibody
|
| |
See all NR0B1 / Dax1 antibodies (10)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Rabbit polyclonal to NR0B1 / Dax1
|
|
Immunogen
|
Synthetic peptide (Human) conjugated to KLH
|
|
Reacts with
(species key)
|
Hu
|
|
Epitope
|
Ligand-binding domain of human NR0B1 / Dax1
|
|
Tested applications
(see key)
|
IHC-P
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
IHC-P: Use at a concentration of 10 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Positive control
(see definition)
|
Human testis
|
|
Cellular localization
|
Nuclear
|
|
Research areas
|
Developmental Biology >> Reproduction >> Placental development
Developmental Biology >> Reproduction >> Sex determination
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Orphan Nuclear Receptors
Chromatin and Nuclear Signaling >> Nuclear Signaling Pathways >> Nuclear Receptors >> Retinoic & Retinoid
Neuroscience >> Endocrine system >> hypothalamic pituitary adrenal axis
Neuroscience >> Endocrine system >> Gonadotrophic axis
|
|
Relevance
|
NR0B1 is a receptor that may be a component of a cascade required for development of steroidogenic tissues. It acts as a dominant negative regulator of transcription mediated by the retinoic acid receptor.
It interacts with COPS2.
Defects in NR0B1 are the cause of X-linked adrenal hypoplasia congenital (AHC). AHC is a developmental disorder of the adrenal gland that results in profound hormonal deficiencies and is lethal if untreated. It is characterized by the absence of the permanent zone of the adrenal cortex and by a structural disorganization of the glands. Hypogonadotropic hypogonadism (HHG) is frequently associated with this disorder. HHG is a condition resulting from or characterized by abnormally decreased gonadal function, with retardation of growth and sexual development.
|
|
|
|
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Rabbit
|
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Purity
|
Immunogen affinity purified
|
|
Storage buffer
|
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.7 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
|
|
Form
|
Liquid
|
|
Storage instructions
|
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this NR0B1 / Dax1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
|
See below for NR0B1 / Dax1 antibody images, references, products related to ab61435 and other tools.
|
| |
NR0B1 / Dax1 antibody images:
|
 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - NR0B1 / Dax1 antibody (ab61435)
Ab61435, at 10 µg/ml, staining human NR0B1 / Dax1 in testis. Formalin fixed, paraffin embedded tissue.
|
| |
| |
|
Search PubMed (MEDLINE) for references to NR0B1 / Dax1
|
| |
NR0B1 / Dax1 antibody - more information
|
Customer reviews (feedback) regarding NR0B1 / Dax1 antibody |
Customer FAQs regarding NR0B1 / Dax1 antibody |
Protocols for NR0B1 / Dax1 antibody |
Price and availability of products related to NR0B1 / Dax1 antibody |
| |
NR0B1 / Dax1 antibody - related products:
|
|
|
| |
NR0B1 / Dax1 antibody - other tools:
|
Contact Abcam with a Technical Enquiry about NR0B1 / Dax1 antibody |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
