Anti-NRL antibody (ab137193)
Key features and details
- Rabbit polyclonal to NRL
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-NRL antibody -
Description
Rabbit polyclonal to NRL -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to the N terminal region of Human NRL (UniProt P54845).
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Positive control
- HUVEC cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS is without Mg2+ and Ca2+. -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab137193 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 26 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 26 kDa. |
Target
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Function
Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. -
Tissue specificity
Neural retina. -
Involvement in disease
Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27) [MIM:162080]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. -
Sequence similarities
Belongs to the bZIP family.
Contains 1 bZIP domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 4901 Human
- Entrez Gene: 18185 Mouse
- Omim: 162080 Human
- SwissProt: P54845 Human
- SwissProt: P54846 Mouse
- Unigene: 652297 Human
- Unigene: 20422 Mouse
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Alternative names
- D14S46E antibody
- Neural retina-specific leucine zipper protein antibody
- Neural retinal specific leucine zipper antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab137193 has been referenced in 1 publication.
- Jamshidi F et al. Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration. Genet Med 21:694-704 (2019). PubMed: 30072743