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Read our guarantee »Overview
Product name
NS 398
Description
COX-2 inhibitor
Biological description
Selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Orally active. Anti-inflammatory, anti-pyretic, analgesic and non-ulcerogenic in vivo. Induces apoptosis and cell cycle arrest.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
Molecular Weight
314.36
Chemical structure
Molecular formula
C13H18N2O5S
CAS Number
123653-11-2
Solubility
Soluble in DMSO
PubChem identifier
0
Storage instructions
Store at room temperature.
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Cyclooxygenase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for NS 398 (ab120295)
This product has been referenced in:
- Du Y et al. Induction of apoptosis and cell cycle arrest by NS398 in oral squamous cell carcinoma cells via downregulation of E2 promoter-binding factor-1. Oncol Rep 20:605-11 (2008).Read more (PubMed: 18695912) »
- Futaki N et al. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47:55-9 (1994).Read more (PubMed: 8140262) »
See all 3 publications for this product
Publishing research using ab120295? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"