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Overview

  • Product nameAnti-NSE2 antibodySee all NSE2 primary antibodies ...
  • Description
    Rabbit polyclonal to NSE2
  • Specificityab105363 is predicted to not crossreact with NSE1.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A 15 amino acid peptide near the C terminus of Human NSE2 (NP_775956).

  • Positive control293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab105363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 28 kDa.

Target

  • FunctionE3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
  • PathwayProtein modification; protein sumoylation.
  • Sequence similaritiesBelongs to the NSE2 family.
    Contains 1 SP-RING-type zinc finger.
  • Post-translational
    modifications    Sumoylated, possibly via autosumoylation.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession Q96MF7 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      C8orf36 antibodyE3 SUMO-protein ligase NSE2 antibodyhMMS21 antibody
      hNSE2 antibodymethyl methanesulfonate sensitivity gene 21 antibodyMMS21 antibodyMMS21 homolog antibodynon-SMC element 2 antibodyNon-SMC element 2 homolog antibodyNon-structural maintenance of chromosomes element 2 homolog antibodyNSE2_HUMAN antibodyNsmce2 antibody
    see all

Anti-NSE2 antibody images

  • Western blot - NSE2 antibody (ab105363)
    Western blot - NSE2 antibody (ab105363)
    Lane 1 : Anti-NSE2 antibody (ab105363) at 0.5 µg/ml
    Lane 2 : Anti-NSE2 antibody (ab105363) at 1 µg/ml

    Lane 1 : 293 cell lysate
    Lane 2 : 293 cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 28 kDa

References for Anti-NSE2 antibody (ab105363)

ab105363 has not yet been referenced specifically in any publications.

Publishing research using ab105363 ? Please let us know so that we can cite the reference in this datasheet

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