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Overview

  • Product nameNUMBL peptideSee all NUMBL proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 200 - 300 of Human NUMBL.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab37500 - NUMBL antibody.
  • Protein length604 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab37500.

    • Protein info

    • Alternative names
        CAG 3ACAG 3ACAG3A
        CAG3ACTG 3aCTG 3aCTG3aCTG3aNBLNBLNUMB Drosophilia Homolog LikeNUMB Drosophilia Homolog LikeNumb homolog (Drosophila) likeNumb homolog likeNumb like proteinNUMB RNumb-like proteinNumb-RNumb-related geneNumb-related proteinNUMBLNUMBL_HUMANNUMBLIKENUMBRNUMBRTNRC 23TNRC 23TNRC23TNRC23Trinucleotide repeat-containing gene 23
      see all
  • FunctionPlays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • Sequence similaritiesContains 1 PID domain.
  • DomainThe PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.
  • Cellular localizationCytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.

    • Target information above from: UniProt accession Q9Y6R0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for NUMBL peptide (ab37499)

    ab37499 has not yet been referenced specifically in any publications.

    Publishing research using ab37499 ? Please let us know so that we can cite the reference in this datasheet

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