Anti-NUP50 antibody (ab130671)

Overview

• Product nameAnti-NUP50 antibodySee all NUP50 primary antibodies ...
• Description
  Rabbit polyclonal to NUP50
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 223-252 of Human NUP50 (NP_009103.2).

• Positive controlWiDr cell lysate.

Properties

• FormLiquid
• Storage instructionsStore at 2-8°C for up to 6 months. For long term storage store at -20°C.
• Storage bufferPreservative: 0.09% Sodium azide
  Constituent: 99% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab130671 was purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Protein Trafficking
  • Nuclear Import / Export

  • Tags & Cell Markers
  • Subcellular Markers
  • Nucleus
  • Nuclear Pore

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Nuclear Pore Complex

  • Cell Biology
  • Apoptosis
  • Nucleus
  • Other

Applications

Target

• FunctionComponent of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.
• Tissue specificityUbiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
• Sequence similaritiesContains 1 RanBD1 domain.
• DomainContains FG repeats.
• Cellular localizationNucleus > nuclear pore complex. Nucleus membrane. Localizes to the nucleoplasmic fibrils of the nuclear pore complex.

Target information above from: UniProt accession Q9UKX7 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 10762 Human
  • Entrez Gene: 10762 Human
  • Omim: 604646 Human
  • SwissProt: Q9UKX7 Human
  • SwissProt: Q9UKX7 Human
  • Unigene: 727643 Human

• Alternative names
  50 kDa nucleoporin antibodyNPAP60 antibodyNPAP60L antibody

  Nuclear pore associated protein 60L antibodyNuclear pore complex protein Nup50 antibodyNuclear pore-associated protein 60 kDa-like antibodynucleoporin 50 antibodyNucleoporin 50kDa antibodyNucleoporin Nup50 antibodyNup50 antibodyNUP50_HUMAN antibodyPRO1146 antibody

  see all

Anti-NUP50 antibody images

• 

  Western blot - Anti-NUP50 antibody (ab130671)
  Anti-NUP50 antibody (ab130671) at 1/100 dilution + WiDr cell lysate at 35 µg
  
  Predicted band size : 50 kDa