You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Related products

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-Nab2 antibody [cl.1C4] (ab11987)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-Nab2 antibody [cl.1C4]
See all Nab2 products (5) ...

Description

Mouse monoclonal [cl.1C4] to Nab2

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Full length protein (Human).

Positive control

K-562 nuclear extract (TPA stimulated).

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide and 0.01% Thiomerosal
Constituents: PBS containing 0.2% Gelatin

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

cl.1C4

Isotype

IgG1

Research areas

Epigenetics and Nuclear Signaling >> Transcription >> Co-factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Neuroscience >> Neurology process >> Neurogenesis

  • - Nab2 antibody [cl.1C4] (ab11987)- Nab2 antibody [cl.1C4] (ab11987) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab11987 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/500 - 1/1000.Detec...Read more →

    WB: 1/500 - 1/1000.Detects a band of approximately 56-65 kDa (predicted molecular weight: 57 kDa).

Target

Function

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability.

Tissue specificity

Widely expressed at low levels. Highly expressed in melanoma cell lines.

Sequence similarities

Belongs to the NAB family.

Domain

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Cellular localization

Nucleus. Isoform 2 is not localized to the nucleus.

Target information above from: UniProt accessionQ15742 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • EGR 1 binding protein 2 antibody
  • EGR-1-binding protein 2 antibody
  • EGR1 binding protein 2 antibody
  • MADER antibody
  • Melanoma associated delayed early response protein antibody
  • Melanoma-associated delayed early response protein antibody
  • MGC75085 antibody
  • Nab 2 antibody
  • nab2 antibody
  • NAB2_HUMAN antibody
  • NGFI A binding protein 2 (EGR1 binding protein 2) antibody
  • NGFI A binding protein 2 antibody
  • NGFI-A-binding protein 2 antibody
  • Protein MADER antibody
see all

Database links

Anti-Nab2 antibody [cl.1C4] images:

  - Nab2 antibody [cl.1C4] (ab11987)

- Nab2 antibody [cl.1C4] (ab11987)

Detection of Nab2 by Western blot analysis. Antibody experiment using Nab2 mouse monoclonal antibody demonstrates the presence of Nab2 transcription factor in nuclear extracts derived from K-562 cells (TPA) using a 1/1000 dilution

References for Anti-Nab2 antibody [cl.1C4] (ab11987)

ab11987 has not yet been referenced specifically in any publications.

Publishing research using ab11987? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"