Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
Overview
Product name
Nanos Homologue 1 (NANOS1) peptide (281-292)
See all Nanos Homologue 1 (NANOS1) products (2) ...
Protein description
Synthetic peptide: C-SARDGPPGKKLR , corresponding to C terminal amino acids 281-292 of Human Nanos Homologue 1 (NANOS1). This peptide was used as an immunogen for ab36163 - Nanos Homologue 1 (NANOS1) antibody.
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Concentration
Concentration information loading...
Sequence
C-SARDGPPG KKLR
Research areas
Developmental Biology >> Reproduction >> Germ cell markers
Stem Cells >> Germline Stem Cells >> Embryonic Germ Cells
Epigenetics and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
Protein info
Function
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Tissue specificity
Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.
Sequence similarities
Belongs to the nanos family.
Contains 1 nanos-type zinc finger.
Developmental stage
Fetal ovary and fetal testis (at protein level).
Domain
The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.
The N-terminal region and C-terminal zinc-finger RNA-binding domain are both necessary for interaction with SNAPIN.
Cellular localization
Cytoplasm > perinuclear region. Cytoplasm. Co-localizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
Target information above from: UniProt accessionQ8WY41
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for Nanos Homologue 1 (NANOS1) peptide (281-292) (ab45711)
ab45711 has not yet been referenced specifically in any publications.
Publishing research using ab45711? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"