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Product Name
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NANOS2 antibody - Primordial Germ Cell Marker
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See all NANOS2 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to NANOS2 - Primordial Germ Cell Marker
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Note on antibody grade |
Fast-Track antibodies
- Immunogen affinity purified
- high ELISA titre values
- released early (to accelerate your research)
- 950 Abpoints to the 1st researcher
who submits conclusive data (positive or negative):
Read the Fast-Track antibody Terms of Use
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Immunogen
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Synthetic peptide derived from residues 50 to the C-terminus of Human Nanos homologue 2 (NANOS2).
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Does not react with
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Ms
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Predicted to react
(species key)
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Hu
(Due to sequence homology)
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Specificity
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This antibody was unable to detect any bands when used in Western Blotting on mouse embryonic germ cell, mouse embryonic stem cell and human embryonic stem cell lysates.
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This antibody gave a positive result in ELISA against the immunising peptide (ab15738).
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Developmental Biology >> Reproduction >> Germ cell markers
Stem Cells >> Germline Stem Cells >> Embryonic Germ Cells
Chromatin and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation
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Relevance
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Nanos is a zinc finger containing, RNA binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2 null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3 null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3 null background. Nanos3 expression can not rescue Nanos2-null defects.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this NANOS2 antibody - Primordial Germ Cell Marker is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to NANOS2
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NANOS2 antibody - Primordial Germ Cell Marker - more information
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Customer reviews (feedback) regarding NANOS2 antibody - Primordial Germ Cell Marker |
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NANOS2 antibody - Primordial Germ Cell Marker - other tools:
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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