NANOS2 peptide (ab15738)

Product Name 

NANOS2 peptide

Product type 

Proteins and Peptides

Peptide 

Synthetic peptide derived from within residues 50 - 150 of Human Nanos homologue 2 (NANOS2). . 

Research areas 

Developmental Biology >> Reproduction >> Germ cell markers
Stem Cells >> Germline Stem Cells >> Embryonic Germ Cells
Chromatin and Nuclear Signaling >> Transcription >> Domain Families >> Zinc Finger
Chromatin and Nuclear Signaling >> DNA / RNA >> Translation >> Regulation

Relevance 

Nanos is a zinc finger containing, RNA binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2 null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3 null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3 null background. Nanos3 expression can not rescue Nanos2-null defects.

Storage buffer 

Preservative: None
Constituents: 0.001% Tween 20, HEPES, 2mM EDTA, 150mM Sodium Chloride

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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