Anti-Natriuretic peptides A antibody [L11-11-D6-B4] (ab14442)
Key features and details
- Mouse monoclonal [L11-11-D6-B4] to Natriuretic peptides A
- Suitable for: ELISA
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Natriuretic peptides A antibody [L11-11-D6-B4]
See all Natriuretic peptides A primary antibodies -
Description
Mouse monoclonal [L11-11-D6-B4] to Natriuretic peptides A -
Host species
Mouse -
Specificity
ab14442 recognizes synthetic Natriuretic peptides A. -
Tested applications
Suitable for: ELISAmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig -
Immunogen
Synthetic peptide corresponding to Human Natriuretic peptides A aa 100 to the C-terminus. Poly Lysin conjugated synthetic peptide.
Database link: P01160 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.40
Constituent: 0.79% Tris HCl -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
Cell culture supernatant, Protein G purified. -
Clonality
Monoclonal -
Clone number
L11-11-D6-B4 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab14442 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
Notes |
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ELISA
Use at an assay dependent concentration. |
Target
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Function
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. -
Involvement in disease
Atrial standstill 2
Atrial fibrillation, familial, 6 -
Sequence similarities
Belongs to the natriuretic peptide family. -
Post-translational
modificationsCleaved by CORIN upon secretion to produce the functional hormone.
Atrial natriuretic factor: Cleaved by MME. The cleavage initiates degradation of the factor and thereby regulate its activity. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 281355 Cow
- Entrez Gene: 608289 Dog
- Entrez Gene: 4878 Human
- Entrez Gene: 230899 Mouse
- Entrez Gene: 397496 Pig
- Entrez Gene: 24602 Rat
- Omim: 108780 Human
- SwissProt: Q9GLD0 Cat
see all -
Alternative names
- ANF antibody
- ANF_HUMAN antibody
- ANP antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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Datasheet download
References (1)
ab14442 has been referenced in 1 publication.
- Bovill E et al. Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. J Thorac Cardiovasc Surg 136:709-16 (2008). PubMed: 18805276