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Product Name
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Nav1.6 antibody
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See all Nav1.6 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Nav1.6
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Note on antibody grade |
Fast-Track antibodies
- Immunogen affinity purified
- high ELISA titre values
- released early (to accelerate your research)
- 950 Abpoints to the 1st researcher
who submits conclusive data (positive or negative):
Read the Fast-Track antibody Terms of Use
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Immunogen
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Synthetic peptide conjugated to KLH derived from within residues 450 - 550 of Mouse Nav1.6. (Peptide available as ab34456.)
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Predicted to react
(species key)
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Hu, Ms, Rat
(Due to sequence homology)
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Abreviews
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Application notes
(see key)
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Recommended dilutions
This antibody gave a positive result in ELISA against the immunizing peptide (ab34456).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Neurotransmission >> Receptors / Channels >> Sodium Channels
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Relevance
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Nav1.6 mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in Nav1.6 are the cause of motor endplate disease, a recessive neuromuscular disorder that is characterized by lack of signal transmission at the neuromuscular junction, excess preterminal arborization and degeneration of cerebellar Purkinje cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Batch dependent within range: 0.20 - 0.40 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Nav1.6 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Nav1.6
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Nav1.6 antibody - more information
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Customer reviews (feedback) regarding Nav1.6 antibody |
Customer FAQs regarding Nav1.6 antibody |
Protocols for Nav1.6 antibody |
Price and availability of products related to Nav1.6 antibody |
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Nav1.6 antibody - related products:
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Nav1.6 antibody - other tools:
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Contact Abcam with a Technical Enquiry about Nav1.6 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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