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Anti-Nav1.6 antibody (ab65166)

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Overview

Product name

Anti-Nav1.6 antibody
See all Nav1.6 products (3) ...

Description

Rabbit polyclonal to Nav1.6

Tested applications

IHC-FrFl, ICC/IF, IHC-P, IHC-Fr, WBmore details

Cross reactivity

Reacts with

Mouse, Human

Predicted to work with

Rat

Immunogen

Synthetic peptide derived from N terminal of human Nav1.6.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: Whole serum

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Neurotransmission >> Receptors / Channels >> Sodium Channels

Applications

Show applications key

Our Abpromise guarantee covers the use of ab65166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation.

Tissue specificity

Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily.
Contains 1 IQ domain.

Domain

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Post-translational
modifications

May be ubiquitinated by NEDD4L; which would promote its endocytosis.

Cellular localization

Membrane and Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.

Target information above from: UniProt accessionQ9UQD0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CerIII antibody
  • hNa6/Scn8a voltage gated sodium channel antibody
  • MED antibody
  • Motor endplate disease antibody
  • NaCh 6 antibody
  • NaCh6 antibody
  • Nav 1.6 antibody
  • Nbna1 antibody
  • PN 4 antibody
  • PN4 antibody
  • Scn8a antibody
  • SCN8A_HUMAN antibody
  • Sodium channel protein type 8 alpha subunit antibody
  • Sodium channel protein type 8 subunit alpha antibody
  • Sodium channel protein type VIII alpha subunit antibody
  • Sodium channel protein type VIII subunit alpha antibody
  • Sodium channel voltage gated type VIII alpha antibody
  • Sodium channel voltage gated type VIII alpha polypeptide antibody
  • Sodium channel voltage gated type VIII alpha subunit antibody
  • Voltage gated sodium channel subunit alpha Nav1.6 antibody
  • Voltage-gated sodium channel subunit alpha Nav1.6 antibody
see all

Database links

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References for Anti-Nav1.6 antibody (ab65166)

This product has been referenced in:

  • Hitt BDet al. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Mol Neurodegener 5:31 (2010). WB; Mouse.Read more (PubMed: 20731874) »

See 1 publication for this product

Publishing research using ab65166? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"