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Product Name
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Nav1.6 antibody
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See all Nav1.6 antibodies (2)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Nav1.6
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Immunogen
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Synthetic peptide derived from N terminal of human Nav1.6.
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Tested applications
(see key)
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ICC/IF, IHC-Fr, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: Use at an assay dependent dilution.
IHC-Fr: Use at an assay dependent dilution.
WB: 1/500 - 1/2000. Predicted molecular weight: 220 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Neuroscience >> Neurotransmission >> Receptors / Channels >> Sodium Channels
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Relevance
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Nav1.6 mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Defects in Nav1.6 are the cause of motor endplate disease, a recessive neuromuscular disorder that is characterized by lack of signal transmission at the neuromuscular junction, excess preterminal arborization and degeneration of cerebellar Purkinje cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Nav1.6 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Nav1.6
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Nav1.6 antibody - more information
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Customer reviews (feedback) regarding Nav1.6 antibody |
Customer FAQs regarding Nav1.6 antibody |
Protocols for Nav1.6 antibody |
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