Anti-Nck antibody [NC-20 (same as 20B-1H9)] (ab44950)

Overview

  • Product nameAnti-Nck antibody [NC-20 (same as 20B-1H9)]See all Nck primary antibodies ...
  • Description
    Mouse monoclonal [NC-20 (same as 20B-1H9)] to Nck
  • Tested applicationsIPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human)

  • Positive control
    • A431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab44950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
  • Application notesIP: 1/400 protein lysate (native and denatured). Use Protein G.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAdapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
    • Sequence similaritiesContains 1 SH2 domain.
      Contains 3 SH3 domains.
    • Post-translational
      modifications
      Phosphorylated on Ser and Tyr residues.
    • Cellular localizationCytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.
    • Information by UniProt
    • Database links
    • Alternative names
      • Cytoplasmic protein NCK1 antibody
      • Melanoma Nck protein antibody
      • MGC12668 antibody
      • NCK 1 antibody
      • NCK adaptor protein 1 antibody
      • NCK alpha antibody
      • NCK antibody
      • NCK tyrosine kinase antibody
      • Nck-1 antibody
      • NCK1 antibody
      • NCK1_HUMAN antibody
      • NCKalpha antibody
      • Non catalytic region of tyrosine kinase antibody
      • SH2/SH3 adaptor protein NCK alpha antibody
      • SH2/SH3 adaptor protein NCK-alpha antibody
      see all

    References for Anti-Nck antibody [NC-20 (same as 20B-1H9)] (ab44950)

    ab44950 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"