You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-Nck antibody [NC-20 (same as 20B-1H9)] (ab44950)

Submit an Abreview Submit a Question

Overview

  • Product nameAnti-Nck antibody [NC-20 (same as 20B-1H9)]See all Nck primary antibodies ...
  • Description
    Mouse monoclonal [NC-20 (same as 20B-1H9)] to Nck
  • Tested applicationsIP more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human)

  • Positive controlA431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab44950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IP
  • Application notesIP: 1/400 protein lysate (native and denatured). Use Protein G.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionAdapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2.
    • Sequence similaritiesContains 1 SH2 domain.
      Contains 3 SH3 domains.
    • Post-translational
      modifications      Phosphorylated on Ser and Tyr residues.
    • Cellular localizationCytoplasm. Endoplasmic reticulum. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires the interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments.

      • Target information above from: UniProt accession P16333 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Cytoplasmic protein NCK1 antibodyMelanoma Nck protein antibodyMGC12668 antibody
          NCK 1 antibodyNCK adaptor protein 1 antibodyNCK alpha antibodyNCK antibodyNCK tyrosine kinase antibodyNck-1 antibodyNCK1 antibodyNCK1_HUMAN antibodyNCKalpha antibodyNon catalytic region of tyrosine kinase antibodySH2/SH3 adaptor protein NCK alpha antibodySH2/SH3 adaptor protein NCK-alpha antibody
        see all

      References for Anti-Nck antibody [NC-20 (same as 20B-1H9)] (ab44950)

      ab44950 has not yet been referenced specifically in any publications.

      Publishing research using ab44950 ? Please let us know so that we can cite the reference in this datasheet

      Product Wall

      Submit an Abreview for ab44950 Submit a Question for ab44950

      There are currently no Abreviews or Questions for ab44950.
      Please use the links above to contact us or submit feedback about this product.

      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"