Overview

  • Product nameAnti-NeuroD1 antibodySee all NeuroD1 primary antibodies ...
  • Description
    Rabbit polyclonal to NeuroD1
  • Tested applicationsIP, WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    A KLH-conjugated synthetic peptide selected from C terminal amino acid region 300-350 of Human NeuroD1 protein.

  • Positive control
    • Mouse lung tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab38552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/1000.
WB 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).
ELISA 1/1000.

Target

  • FunctionDifferentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • Involvement in diseaseDefects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • atonal antibody
    • basic helix loop helix transcription factor antibody
    • BETA 2 antibody
    • Beta cell E box transactivator 2 antibody
    • BETA2 antibody
    • BETA2 antibody
    • BHF 1 antibody
    • BHF1 antibody
    • BHF1 antibody
    • bHLHa3 antibody
    • class A basic helix loop helix protein 3 antibody
    • Class A basic helix-loop-helix protein 3 antibody
    • MODY 6 antibody
    • MODY6 antibody
    • NDF1_HUMAN antibody
    • NEUROD antibody
    • NeuroD1 antibody
    • Neurogenic differentiation 1 antibody
    • Neurogenic differentiation factor 1 antibody
    • Neurogenic differentiation factor 1 antibody
    • neurogenic helix loop helix protein NEUROD antibody
    • NIDDM antibody
    • NIDDM antibody
    see all

Anti-NeuroD1 antibody images

  • Anti-NeuroD1 antibody (ab38552) at 1/1000 dilution + Mouse lung tissue lysate

    Predicted band size : 40 kDa
    Observed band size : 40 kDa
    Additional bands at : 26 kDa,32 kDa. We are unsure as to the identity of these extra bands.

References for Anti-NeuroD1 antibody (ab38552)

ab38552 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I am sorry for the confusion. This antibody reacts and is guaranteed to work against human and murine NeuroD1. I have amended the datasheet to reflect this. The antibody works for both IP and WB. I hope this informati...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"