Overview

  • Product nameAnti-NeuroD1 antibody
    See all NeuroD1 primary antibodies
  • Description
    Rabbit polyclonal to NeuroD1
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human NeuroD1 aa 318-348 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Database link: Q13562

  • Positive control
    • WB: Mouse lung and cerebellum tissue lysates, rat brain tissue lysate and Y79 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab38552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 40 kDa).

Target

  • FunctionDifferentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
  • Involvement in diseaseDefects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • atonal antibody
    • basic helix loop helix transcription factor antibody
    • BETA 2 antibody
    • Beta cell E box transactivator 2 antibody
    • BETA2 antibody
    • BETA2 antibody
    • BHF 1 antibody
    • BHF1 antibody
    • BHF1 antibody
    • bHLHa3 antibody
    • class A basic helix loop helix protein 3 antibody
    • Class A basic helix-loop-helix protein 3 antibody
    • MODY 6 antibody
    • MODY6 antibody
    • NDF1_HUMAN antibody
    • NEUROD antibody
    • NeuroD1 antibody
    • Neurogenic differentiation 1 antibody
    • Neurogenic differentiation factor 1 antibody
    • Neurogenic differentiation factor 1 antibody
    • neurogenic helix loop helix protein NEUROD antibody
    • NIDDM antibody
    • NIDDM antibody
    see all

Anti-NeuroD1 antibody images

  • All lanes : Anti-NeuroD1 antibody (ab38552)

    Lane 1 : Y79 cell lysate
    Lane 2 : Mouse cerebellum tissue lysate
    Lane 3 : Rat brain tissue lysate

    Lysates/proteins at 35 µg per lane.


    Predicted band size : 40 kDa
  • Anti-NeuroD1 antibody (ab38552) at 1/1000 dilution + Mouse lung tissue lysate

    Predicted band size : 40 kDa
    Observed band size : 40 kDa
    Additional bands at : 26 kDa,32 kDa. We are unsure as to the identity of these extra bands.
    Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

References for Anti-NeuroD1 antibody (ab38552)

ab38552 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I am sorry for the confusion. This antibody reacts and is guaranteed to work against human and murine NeuroD1. I have amended the datasheet to reflect this. The antibody works for both IP and WB. I hope this informati...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"