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Products:Neuroscience >> Neurotransmitter >> Neuropeptides >> Tachykinins
Overview
Product name
Anti-Neurokinin 1 Receptor antibody
See all Neurokinin 1 Receptor products (3) ...
Description
Rabbit polyclonal to Neurokinin 1 Receptor
Specificity
This antibody is specific for human NK-1.
Tested applications
Flow Cyt, WB, ICC/IFmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide with a cysteine added for conjugation to KLH.
Epitope
N-MDNVLPVDSDLSPNISTC-COOH
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurotransmitter >> Neuropeptides >> Tachykinins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab466 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
ICC/IF
Application notes
Flow Cyt: 1/3000.
ICC/IF: 1/5000 from (PubMed:17190739).
WB: 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 45 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP25103
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Neurokinin 1 antibody
- NK 1 receptor antibody
- NK 1R antibody
see all
Database links
- Entrez Gene: 6869 Human
- Omim: 162323 Human
- SwissProt: P25103 Human
- Unigene: 633301 Human
References for Anti-Neurokinin 1 Receptor antibody (ab466)
This product has been referenced in:
- El-Nour Het al. Upregulation of the axonal growth and the expression of substance P and its NK1 receptor in human allergic contact dermatitis. Immunopharmacol Immunotoxicol 28:621-31 (2006).Read more (PubMed: 17190739) »
- Amoruso Aet al. A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor-gamma protein expression in human monocytes and macrophages. Br J Pharmacol 154:144-52 (2008). WB; Human.Read more (PubMed: 18278062) »
See all 4 publications for this product
Publishing research using ab466? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"