Overview
Product nameNeuropilin 1 peptideSee all Neuropilin 1 proteins and peptides ...
Protein descriptionSynthetic peptide corresponding to amino acids in the a1 CUB domain of human Neuropilin 1.
This peptide was used as an immunogen for ab25998 - Neuropilin 1 antibody.
Properties
Purity> 90
% by SDS-PAGE
Biological activityThis peptide is highly conserved in rat and mouse Neuropilin 1 and has low homology to Neuropilin 2.
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.05% Sodium Azide
Constituents: PBS
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab42720
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Application
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Notes |
| Blocking |
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| ELISA |
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Application notesBL: Use at a concentration of 1 µg/ml. (Western blot and immunocytochemistry).
ELISA: Use at a concentration of 10-100 ng/well.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
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Alternative names
A5 proteinBDCA4BLOOD DENDRITIC CELL ANTIGEN 4
CD 304CD304DKFZp686A03134DKFZp781F1414Neuropilin-1Neuropilin1Neuropilin1 transmembrane receptorNP1NPN1NRPNRP 1NRP1NRP1_HUMANVascular endothelial cell growth factor 165 receptorVEGF165R
see all
FunctionThe membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.
Tissue specificityThe expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Sequence similaritiesBelongs to the neuropilin family.
Contains 2 CUB domains.
Contains 2 F5/8 type C domains.
Contains 1 MAM domain.
Cellular localizationSecreted and Cell membrane.
References for Neuropilin 1 peptide (ab42720)
ab42720
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
