Overview

  • Product nameAnti-Neuroserpin antibody
    See all Neuroserpin primary antibodies
  • Description
    Mouse monoclonal to Neuroserpin
  • Tested applicationsWB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 17-411 of Human Neuroserpin

Properties

Applications

Our Abpromise guarantee covers the use of ab55587 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 46 kDa.
IHC-P Use a concentration of 3 µg/ml.

Target

  • FunctionSerine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.
  • Tissue specificityPredominantly expressed in the brain.
  • Involvement in diseaseDefects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.
  • Sequence similaritiesBelongs to the serpin family.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp781N13156 antibody
    • Neuroserpin antibody
    • NEUS_HUMAN antibody
    • Peptidase inhibitor 12 antibody
    • PI-12 antibody
    • PI12 antibody
    • Protease inhibitor 12 antibody
    • Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1 antibody
    • Serine or cysteine proteinase inhibitor clade I member 1 antibody
    • Serpin I1 antibody
    • Serpin peptidase inhibitor clade I (neuroserpin) member 1 antibody
    • SERPINI1 antibody
    see all

Anti-Neuroserpin antibody images

  • Neuroserpin antibody (ab55587) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human cerebral cortex.


  • Predicted band size : 46 kDa
    Neuroserpin antibody (ab55587) at 1ug/lane + HeLa cell lysate at 25ug/lane.

References for Anti-Neuroserpin antibody (ab55587)

This product has been referenced in:
  • Wong TH  et al. PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology. Brain 137:1361-73 (2014). Read more (PubMed: 24722252) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Human Tissue sections (Brain)
Specification Brain
Fixative Formaldehyde
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: EDTA
Permeabilization No
Blocking step Serum as blocking agent for 20 minute(s) · Concentration: 10% · Temperature: RT°C
Username

Dr. Rachel Barker

Verified customer

Submitted Jan 07 2010

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Tissue lysate - whole (Brain)
Loading amount 30 µg
Specification Brain
Treatment Homogenised in 1% SDS lysis buffer
Gel Running Conditions Reduced Denaturing (4-20% Tris-HCl gel)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: RT°C
Username

Dr. Rachel Barker

Verified customer

Submitted Nov 30 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"